Role of aquaporin in retinal and optic nerve degenerative disorders
| Project/Area Number |
26462661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山田 裕子 神戸大学, 医学研究科, 講師 (00359861)
金森 章泰 神戸大学, 医学研究科, 非常勤講師 (10444572)
三木 明子 神戸大学, 医学部附属病院, 助教 (10726988)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 視神経脊髄炎 / 緑内障 / 網膜神経節細胞 / アクアポリン / ヒト化免疫グロブリン / 光干渉断層計 / アクアポリン４ / 難治視神経疾患 / 乳酸 / アポトーシス |
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| Outline of Final Research Achievements |
An experimental neuromyelitis optica (NMO) model was established by exposing the rat optic nerve to sera from patients with anti-aquaporin 4 (AQP4) antibody-positive optic neuritis. Intravenous humanized immunogloblin G substantilly reduced the retinal ganglion cell (RGC) death. We demonstrated that the way how the AQP4 antibody positive optic neuritis damages the retinal tissue was different from the AQP4 antibody negative cases. We showed lacate transport through aquaporin 9 channel to be critical for the RGC survival.
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Report
(4 results)
Research Products
(20 results)
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[Presentation] 周辺視野を守る。2014
Author(s)
中村 誠
Organizer
第25回日本緑内障学会
Place of Presentation
大阪国際会議場
Year and Date
2014-09-20 – 2014-09-22
Related Report
Invited
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