Investigation of autophagy-regulated mechanism of vascular cell death in early diabetic retinopathy
| Project/Area Number |
26462671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Takagi Hitoshi 聖マリアンナ医科大学, 医学部, 教授 (70283596)
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| Co-Investigator(Kenkyū-buntansha) |
北岡 康史 聖マリアンナ医科大学, 医学部, 准教授 (10367352)
宗正 泰成 聖マリアンナ医科大学, 医学部, 講師 (30440340)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAKURA Nobuyuki 大阪大学, 微生物学研究所, 教授 (80291954)
KOYA Daisuke 金沢医科大学, 医学部, 教授 (70242980)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | オートファジー / 糖尿病網膜症 / 網膜血管細胞死 |
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| Outline of Final Research Achievements |
Vascular cell death causes diabetic retinopathy and autophagy has been paid attention as a novel cell death mechanism. We compared gene expression between low and high glucose - stimulated vascular endothelial cells. High glucose-stimulation induced inflammatory and thrombotic effects in gene expression profile in vascular cells. TGFB2 specially upregulated and mediated cell death. High glucose condition upregulated autophagy and inhibited TNF-induced P62 increase, which are reversed by inhibition of autophagy reflux. These finding suggests that autophagy regulation could be applied to future treatment strategies.
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Report
(4 results)
Research Products
(67 results)
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[Presentation] 糖尿病網膜症の病態と治療2016
Author(s)
高木 均
Organizer
角膜カンファランス2016 ランチョンセミナー
Place of Presentation
軽井沢プリンスホテル(長野県北佐久郡）
Year and Date
2016-02-19
Related Report
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[Presentation] HistoneH2B, a potential role of cell death ligand, induced RGC death through Toll like receptor 4 in the vitreous of acute angle closure2016
Author(s)
Munemasa Y,Kitaoka Y, Sase K,Kojima K,Shiono A, Kogo J, Tokuda N, Takagi H
Organizer
2016 annual meeting of The Association for Research in Vision and Ophthalmology
Place of Presentation
Seattle,USA
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[Presentation] ドルゾラミド/チモロール配合剤とブリンゾラミド／チモロール配合剤の涙液動態への影響2016
Author(s)
畑 真由美,徳田直人,松澤亜紀子,星 桃子,鍬塚友子,春日弘子,大島香代,秋山由紀,中村有希,高橋香莉,大宮郁未,高木 均.
Organizer
第70回 日本臨床眼科学会
Place of Presentation
国立京都国際会館(京都府京都市）
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[Presentation] 黄斑手術治療法の近況2014
Author(s)
高木 均
Organizer
第45回熊本眼疾患研究会
Place of Presentation
熊本市医師会館（熊本）
Year and Date
2014-10-25
Related Report
Invited
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[Presentation] 近視黄斑円孔手術の経過2014
Author(s)
高木 均
Organizer
第16回Japan Macula Club
Place of Presentation
蒲郡クラシックホテル（蒲郡市）
Year and Date
2014-08-23
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