Regulation of uveitis by inhibition of IkappaB kinase in mice
Project/Area Number |
26462675
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Hokkaido University |
Principal Investigator |
Ishijima Kan 北海道大学, 大学病院, 医員 (70634765)
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Co-Investigator(Kenkyū-buntansha) |
北市 伸義 北海道医療大学, 個体差医療科学センター, 教授 (40431366)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | ぶどう膜炎 / 転写因子 / 新規薬剤 / 実験的自己免疫性ぶどう膜網膜炎 / IkappaB阻害薬 |
Outline of Final Research Achievements |
A new IkappaB kinase inhibitor, IMD-0354, was systemically injected into an animal model of human endogenous uveitis. Clinical severity of uveitis was significantly milder in treated mice than that of untreated control mice (p<0.05). It showed a dose-dependet effect. Pathological severity was also significantly milder in treated mice than controls (p<0.05). A new IkappaB inhibitor had a beneficial effect on regulating uveitis in mice.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population.2016
Author(s)
Kaori Higashia, Akira Meguroa, Masaki Takeuchiab, Takahiro Yamanea, Nobuyoshi Kitaichic, Yukihiro Horiec, Kenichi Nambad, Shigeaki Ohnod, Kumiko Nakaoe, Taiji Sakamotoe, at el.
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Journal Title
Ophthalmic Genetics
Volume: -
Issue: 2
Pages: 187-189
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma.2016
Author(s)
Dong Z, Shinmei Y, Dong Y, Inafuku S, Fukuhara J, Ando R, Kitaichi N, Kanda A, Tanaka K, Noda K, Harada T, Chin S, Ishida S.
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Journal Title
Heliyon
Volume: 2
Issue: 10
Pages: e00191-e00191
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ocular Behcet’s disease is less complicated with allergic disorders. A nationwide survey in Japan.2016
Author(s)
Horie Y, Kitaichi N, Hijioka K, Sonoda K, Saishin Y, Kezuka T, Goto H, Takeuchi M, Nakamura S, Kimoto T, Shimakawa M, Kita M, Sugita S, Mochizuki M, Hori J, Iwata M, Shoji J, Fukuda M, Kaburaki T, Numaga J, Kawashima H, Fukushima A, Joko T, Takai N, Ozawa Y, Meguro A, Mizuki N, Namba K, Ishida S, Ohno S.
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Journal Title
Clin Exp Rheumatol.
Volume: 102
Pages: 1100-1105
Related Report
Peer Reviewed
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[Journal Article] Invariant natural killer T cells play dual roles in the development of experimental autoimmune uveoretinitis.2016
Author(s)
Satoh M, Namba K, Kitaichi N, Endo N, Kitamei H, Iwata D, Ohno S, Ishida S, Onoe K, Watarai H, Taniguchi M, Ishibashi T,
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Journal Title
Exp Eye Res.
Volume: 153
Pages: 79-89
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease.2016
Author(s)
Tagawa Y, Namba K, Mizuuchi K, Takemoto Y, Iwata D, Uno T, Fukuhara T, Hirooka K, Kitaichi N, Ohno S, Ishida S
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Journal Title
Br J Ophthalmol
Volume: 100
Issue: 4
Pages: 473-477
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia.2015
Author(s)
Lennikov A, Alekberova Z, Goloeva R, Kitaichi N, Denisov L, Namba K, Takeno M, Ishigatsubo Y, Mizuki N, Nasonov E, Ishida S, Ohno S.
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Journal Title
Clin Rheumatol
Volume: 34
Issue: 2
Pages: 321-327
DOI
Related Report
Peer Reviewed
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[Journal Article] Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde derived-advanced glycation end product formation.2014
Author(s)
Dong Z, Iwata D, Kitaichi N, Takeuchi M, Sato M, Endo N, Iwabuchi K, Ando R, Fukuhara J, Kinoshita S, Lennikov A, Kitamura M, Mizuuchi K, Kanda A, Noda K, Namba K, Yamagishi S, Ohno S, Ishida S
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Journal Title
J Leukoc Biol
Volume: 96
Issue: 6
Pages: 1077-1085
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Evolutionary origins of human adenovirus types 8 and 542014
Author(s)
Kitaichi N, Yamane S, Gonzalez G, Panto L, Okuyama Y, Kaneko H, Wadell G, Gordon YJ, Yawata N, Albert Heim A, Koyanagi KO, Aoki A, Watanabe H
Organizer
11th International Adenovirus Meeting
Place of Presentation
La jolla(California,USA)
Year and Date
2014-07-16 – 2014-07-20
Related Report
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