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Exploratory study of novel neuroprotective treatment using microglia macrophages

Research Project

Project/Area Number 26462677
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

Maruyama Kazuichi  東北大学, 大学病院, 講師 (10433244)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsマイクログリア / マクロファージ / 緑内障 / NRF-2 / BDNF / ミクログリア
Outline of Final Research Achievements

The pathology of glaucoma is thought to be RGC death caused by obstruction of optic nerve axon flow to retinal ganglion cells (RGC). Various inflammatory or anti-inflammatory cytokines / chemokines are involved in the course of RGC death, and these cytokines / chemokines are produced from microglia, mueller cells or macrophages recruited into the retina after injury It is thought that. In this study, we observed microglia / macrophage kinetics at the time of disorder, and it turned out that cells associated with RGC death were macrophages and those with neuroprotective effect to suppress RGC death were microglia.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Vitreous lavage fluid and bronchoalveolar lavage fluid have equal diagnostic value in sarcoidosis.2016

    • Author(s)
      Maruyama K, Inaba T, Tamada T, Nakazawa T.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Erratum: Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography: erratum.2016

    • Author(s)
      Yamanari M, Tsuda S, Kokubun T, Shiga Y, Omodaka K, Aizawa N, Yokoyama Y, Himori N, Kunimatsu-Sanuki S, Maruyama K, Kunikata H, Nakazawa T.
    • Journal Title

      Biomed Opt Express

      Volume: 18 Pages: 46364638-46364638

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients.2016

    • Author(s)
      Takada N, Omodaka K, Kikawa T, Takagi A, Matsumoto A, Yokoyama Y, Shiga Y, Maruyama K, Takahashi H, Akiba M, Nakazawa T.
    • Journal Title

      PLoS One

      Volume: 24

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Topical ocular dexamethasone decreases intraocular pressure and body weight in rats.2016

    • Author(s)
      Sato K, Nishiguchi KM, Maruyama K, Moritoh S, Fujita K, Ikuta Y, Kasai H, Nakazawa T.
    • Journal Title

      J Negat Results Biomed.

      Volume: 12 Pages: 15-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma.2016

    • Author(s)
      Himori N, Kunikata H, Shiga Y, Omodaka K, Maruyama K, Takahashi H, Nakazawa T.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 254 Pages: 333341-333341

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?2015

    • Author(s)
      Heindl LM, Kaser-Eichberger A, Schlereth SL, Bock F, Regenfuss B, Reitsamer HA, McMenamin P, Lutty GA, Maruyama K, Chen L, Dana R, Kerjaschki D, Alitalo K, De Stefano ME, Junghans BM, Schroedl F, Cursiefen C.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 56 Issue: 11 Pages: 6709-6710

    • DOI

      10.1167/iovs.15-17686

    • Related Report
      2015 Research-status Report
  • [Journal Article] Stage-specific reference genes significant for quantitative PCR during mouse retinal development.2015

    • Author(s)
      Adachi, H., Tominaga, H., Maruyama, Y., Yoneda, K., Maruyama, K., Yoshii, K., Kinoshita, S., Nakano, M., Tashiro, K.
    • Journal Title

      Genes Cells

      Volume: 20 Issue: 8 Pages: 625-635

    • DOI

      10.1111/gtc.12254

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular, anatomical and functional changes in the retinal ganglion cells after optic nerve crush in mice2015

    • Author(s)
      Yukita M, Machida S, Nishiguchi KM, Tsuda S, Yokoyama Y, Yasuda M, Maruyama K, Nakazawa T.
    • Journal Title

      Doc Ophthalmol.

      Volume: 130 Issue: 2 Pages: 149-156

    • DOI

      10.1007/s10633-014-9478-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical neuroprotective roles of heme oxygenase-1 induction against axonal injury-induced retinal ganglion cell death.2014

    • Author(s)
      8.Himori N, Maruyama K, Yamamoto K, Yasuda M, Ryu M, Omodaka K, Shiga Y, Tanaka Y, Nakazawa T.
    • Journal Title

      J Neurosci Res

      Volume: 9 Issue: 9 Pages: 1134-42

    • DOI

      10.1002/jnr.23398

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroprotective effect against axonal damage-induced retinal ganglion cell death in apolipoprotein E-deficient mice through the suppression of kainate receptor signaling.2014

    • Author(s)
      10.Omodaka K, Nishiguchi KM, Yasuda M, Tanaka Y, Sato K, Nakamura O, Maruyama K, Nakazawa T.
    • Journal Title

      Brain Res

      Volume: 1586 Pages: 203-212

    • DOI

      10.1016/j.brainres.2014.08.053

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of calpain in an in vivo model of oxidative stress-induced retinal ganglion cell damage2014

    • Author(s)
      Yu Yokoyama, Kazuichi Maruyama, Kotaro Yamamoto, Kazuko Omodaka, Masayuki Yasuda, Noriko Himori, Morin Ryu, Koji M. Nishiguchi, Toru Nakazawa
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 451 Issue: 4 Pages: 510-515

    • DOI

      10.1016/j.bbrc.2014.08.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of podoplanin inhibition on lymphangiogenesis under pathological conditions.2014

    • Author(s)
      5.Maruyama Y, Maruyama K, Kato Y, Kajiya K, Moritoh S, Yamamoto K, Matsumoto Y, Sawane M, Kerjaschki D, Nakazawa T, Kinoshita S
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 8 Pages: 4813-4822

    • DOI

      10.1167/iovs.13-13711

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 再発型Vogt-小柳-原田病におけるシクロスポリン有用性の検討2016

    • Author(s)
      丸山和一
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都市 京都国際会議場
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経保護におけるマクロファージと ミクログリア(マイクログリア)の役割2016

    • Author(s)
      丸山 和一
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] あたらしい眼科2016

    • Author(s)
      丸山 和一
    • Total Pages
      6
    • Publisher
      メディカル葵出版
    • Related Report
      2016 Annual Research Report
  • [Book] 医学のあゆみ2016

    • Author(s)
      丸山 和一
    • Total Pages
      3
    • Publisher
      医歯薬出版
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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