Development of a novel method to measure visual field

• Project/Area Number: 26462679
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: The University of Tokyo
• Principal Investigator: Asaoka Ryo 東京大学, 医学部附属病院, 特任講師 (00362202)
• Research Collaborator: MURATA HIROSHI 東京大学, 医学部附属病院, 助教 (80635748) ; FUJINO YURI 東京大学, 医学部附属病院, 特任研究員 (20768254) ; MATSUURA MASATO 東京大学, 医学部附属病院, 特任研究員 (00768351)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 緑内障 / 視野進行予測 / 視野測定

Outline of Final Research Achievements

A database of glaucomatous visual field was developed with 1348 eyes from 10 institutes in Japan. Using this database, it was suggested it was useful to regress visual field result against intraocular pressure integrated time rather than regressing against time. Also, it was suggested it was usefl to use deep learning method to detect early glaucomatous visual field change. It was suggested it was useful to combine these approaches with the variational Bayes linear regression, and the development of visual field measurement algorithm using these outcomes is on-going.

Research Products

• [Journal Article] The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma (2017)
  • Author(s): Matsuura M, Hirasawa K, Murata H, Nakakura S, Kiuchi Y, Asaoka R
  • Journal Title: Sci Rep Volume: 17 Issue: 1 Pages: 40798-40798
  • DOI: 10.1038/srep40798
  • Peer Reviewed / Open Access
• [Journal Article] Developing an Item Bank to Measure Quality of Life in Individuals With Glaucoma, and the Results of the Interview With Patients: The Effect of Visual Function, Visual Field Progression Rate, Medical, and Surgical Treatments on Quality of Life (2017)
  • Author(s): Matsuura M, Hirasawa K, Hirasawa H, Yanagisawa M, Murata H, Mayama C, Asaoka R
  • Journal Title: J glaucoma Volume: 26 Issue: 2 Pages: e64-e73
  • DOI: 10.1097/ijg.0000000000000554
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG). (2016)
  • Author(s): Fujino Y, Asaoka R, Murata H, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57 Issue: 4 Pages: 2012-2020
  • DOI: 10.1167/iovs.15-19046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel method to predict visual field progression more accurately, using intraocular pressure measurements in glaucoma patients (2016)
  • Author(s): Asaoka R, Fujino Y, Murata H, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N, Japanese Archive of Multicentral Database in Glaucoma (JAMDIG) construction group
  • Journal Title: Sci Rep Volume: 26 Issue: 1 Pages: 31728-31728
  • DOI: 10.1038/srep31728
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of ocular and systemic factors on the progression of glaucomatous visual field damage in various sectors. (2016)
  • Author(s): Asaoka R, Murata H, Fujino Y, Hirasawa K, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Miki A, Shoji N
  • Journal Title: Br J Ophthalmol. Volume: － Issue: 8 Pages: 1071-1075
  • DOI: 10.1136/bjophthalmol-2016-309643
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Detecting Preperimetric Glaucoma with Standard Automated Perimetry Using a Deep Learning Classifier (2016)
  • Author(s): Asaoka R, Murata H, Iwase A, Araie M
  • Journal Title: Ophthalmology Volume: 123 Issue: 9 Pages: 1974-1980
  • DOI: 10.1016/j.ophtha.2016.05.029
  • Peer Reviewed
• [Journal Article] Validating the Usefulness of the "Random Forests" Classifier to Diagnose Early Glaucoma With Optical Coherence Tomography (2016)
  • Author(s): Asaoka R, Hirasawa K, Iwase A, Fujino Y, Murata H, Shoji N, Araie M
  • Journal Title: Am J Ophthalmol Volume: 174 Pages: 95-103
  • DOI: 10.1016/j.ajo.2016.11.001
  • Peer Reviewed
• [Journal Article] The usefulness of gaze tracking as an index of visual field reliability in glaucoma patients. (2015)
  • Author(s): Ishiyama Y, Murata H, Hirasawa H, Asaoka R.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56 Issue: 13 Pages: 7801-7805
  • DOI: 10.1167/iovs.15-17988
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The usefulness of gaze tracking as an index of visual field reliability in glaucoma patients. (2015)
  • Author(s): Ishiyama Y, Murata H, Asaoka R
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56 Issue: 11 Pages: 6233-6
  • DOI: 10.1167/iovs.15-17661
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Applying 'Lasso' regression to predict future visual field progression in glaucoma (2015)
  • Author(s): Y. Fujino, H. Murata, C. Mayama and R. Asaoka
  • Journal Title: Investigative ophthalmology & visual science Volume: 56 Issue: 4 Pages: 2334-9
  • DOI: 10.1167/iovs.15-16445
  • Peer Reviewed / Open Access
• [Journal Article] A new approach to measure visual field progression in glaucoma patients using variational bayes linear regression (2014)
  • Author(s): H. Murata, M. Araie and R. Asaoka
  • Journal Title: Investigative ophthalmology & visual science Volume: 12 Issue: 12 Pages: 8386-8392
  • DOI: 10.1167/iovs.14-14625
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An objective evaluation of gaze tracking in Humphrey perimetry and the relation with the reproducibility of visual fields: a pilot study in glaucoma (2014)
  • Author(s): Y. Ishiyama, H. Murata, C. Mayama and R. Asaoka
  • Journal Title: Investigative ophthalmology & visual science Volume: 55 Issue: 12 Pages: 8149-52
  • DOI: 10.1167/iovs.14-15541
  • Peer Reviewed / Open Access
• [Journal Article] Clustering visual field test points based on rates of progression to improve the prediction of future damage. (2014)
  • Author(s): Hirasawa K, Murata H, Hirasawa H, Mayama C, Asaoka R.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 55 Issue: 11 Pages: 7681-5
  • DOI: 10.1167/iovs.14-15040
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of various machine learning methods to predict vision-related quality of life from visual field data and visual acuity in patients with glaucoma. (2014)
  • Author(s): Hirasawa H, Murata H, Mayama C, Araie M, Asaoka R.
  • Journal Title: Br J Ophthalmol. Volume: 98(9) Issue: 9 Pages: 1230-5
  • DOI: 10.1136/bjophthalmol-2013-304319
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identifying "preperimetric" glaucoma in standard automated perimetry visual fields (2014)
  • Author(s): Asaoka R, Iwase A, Hirasawa K, Murata H, Araie M
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 12 Issue: 12 Pages: 7814-7820
  • DOI: 10.1167/iovs.14-15120
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Relationship between Central Visual Field Damage and Motor Vehicle Collisions in Primary Open-Angle Glaucoma Patients (2014)
  • Author(s): Yuki K, Asaoka R, Tsubota K
  • Journal Title: PlosOne Volume: 12 Issue: 12 Pages: e115572-e115572
  • DOI: 10.1371/journal.pone.0115572
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] To diagnose glaucoma based on spectral domain optical coherence tomography (SD-OCT) measurements using the 'Random Forests’ method. (2017)
  • Author(s): 朝岡亮
  • Organizer: 32nd Asia-Pacific Academy of Ophthalmology
  • Place of Presentation: Singapore
  • Year and Date: 2017-03-01
  • Int'l Joint Research / Invited
• [Presentation] Investigation of the usefulness of Octopus EyeSuite’s Cluster Trend Analysis (2016)
  • Author(s): 朝岡亮、村田博史
  • Organizer: United Kingdom and Eire Glaucoma Society
  • Place of Presentation: 英国、チェルトナム
  • Year and Date: 2016-11-06
• [Presentation] Adjusting circumpapillary retinal nerve fiber layer thickness profile measured with optical coherence tomography using the retinal artery position improves the structure-function relationship (2016)
  • Author(s): Fujino Y, Yamashita T, Yanagisawa M, Murata H, Asaoka R
  • Organizer: 国際視野学会
  • Place of Presentation: Italy, Udine
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] The usefulness of CorvisST and the Ocular Response Analyzer to assess the progression of glaucoma (2016)
  • Author(s): Matsuura M, Hirasawa K, Murata H, Nakao Y, Nakakura S, Kiuchi Y, Asaoka R
  • Organizer: 国際視野学会
  • Place of Presentation: Italy, Udine
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] Validating variational Bayes linear regression model with multicentral data (2016)
  • Author(s): Murata H, Fujino Y, Asaoka R
  • Organizer: 国際視野学会
  • Place of Presentation: Italy, Udine
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] Investigating the usefulness of cluster trend analysis (2016)
  • Author(s): Aoki S, Murata H, Asaoka R
  • Organizer: 国際視野学会
  • Place of Presentation: Italy, Udine
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] 網膜動脈位置での補正による緑内障における構造機能連関の改善 (2016)
  • Author(s): 藤野友里、山下高明、柳沢美衣子、村田博史、朝岡亮
  • Organizer: 第２７回日本緑内障学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-17
• [Presentation] Corvis STによる角膜生体力学的特性と緑内障視野進行速度の関連の検討 (2016)
  • Author(s): 松浦将人、平澤一法、村田博史、中尾善隆、中倉俊佑、木内良明、朝岡亮
  • Organizer: 第２７回日本緑内障学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-17
• [Presentation] 日本人後ろ向き多施設緑内障データベース(JAMDIG) 緑内障視野進行の評価 (2016)
  • Author(s): 藤野友里、朝岡亮、村田博史、三木篤也、谷戸正樹、溝上史郎、森和彦、鈴木克佳、山下高明、柏木賢治、庄司信行
  • Organizer: 第5回日本視野学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-14
• [Presentation] 緑内障の機能―構造解析におけるゲイズトラック記録および信頼性指標の有用性 (2016)
  • Author(s): 平澤裕代、石山由佳子、村田博史、朝岡亮
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Presentation] 緑内障の構造－機能解析におけるゲイズトラック記録および信頼性指標の有用性 (2016)
  • Author(s): 平澤裕代、村田博史、朝岡亮
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Presentation] Data augmentation for predicting future visual field. (2016)
  • Author(s): Murata H, Asaoka R
  • Organizer: World Ophthalmology Conference
  • Place of Presentation: メキシコ、Guadalajara
  • Year and Date: 2016-02-05
  • Int'l Joint Research
• [Presentation] タイムシフトによる視野予測改善 (2015)
  • Author(s): 村田博史、朝岡亮
  • Organizer: 第26回日本緑内障学会
  • Place of Presentation: ウィンク愛知（愛知県名古屋市）
  • Year and Date: 2015-09-12
• [Presentation] 視野予測モデルの予測誤差に及ぼす因子の検討 (2015)
  • Author(s): 村田博史、朝岡亮
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16 – 2015-04-19
• [Presentation] 緑内障・視神経症「緑内障診断・現在と近未来」 (2015)
  • Author(s): 朝岡亮
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16
  • Invited
• [Presentation] MDとゲイズトラッキング、視野信頼性指標の関連に関する検討 (2014)
  • Author(s): 石山 由佳子、村田博史、間山千尋、朝岡亮
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-13 – 2014-10-16
• [Presentation] ﾍﾞｲｽﾞ線形回帰を用いた視野予測 (2014)
  • Author(s): 村田博史、朝岡亮
  • Organizer: 第68回日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-13 – 2014-10-16
• [Presentation] シンポジウム 視野検査を活かして守る -the goal of visual field test- 統計解析で守る (2014)
  • Author(s): 朝岡亮
  • Organizer: 第25回日本緑内障学会 2014 大阪
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-19 – 2014-09-21
  • Invited
• [Presentation] The gaze tracking and the test-retest reproducibility of visual field (2014)
  • Author(s): Ishiyama Y, Murata H, Mayama C, Asaoka R.
  • Organizer: 21th International Imaging and Perimetry Symposium
  • Place of Presentation: New York
  • Year and Date: 2014-09-09 – 2014-09-12
• [Presentation] Comparisons of robust linear regression and simple linear regression models in predicting visual field progression (2014)
  • Author(s): Taketani Y, Murata H, Asaoka R
  • Organizer: 21th International Imaging and Perimetry Symposium
  • Place of Presentation: New York
  • Year and Date: 2014-09-09 – 2014-09-12
• [Patent(Industrial Property Rights)] 視野検査装置 (2016)
  • Inventor(s): 山西健司、上坂俊允、森野 佳生、朝岡亮、村田博史
  • Industrial Property Rights Holder: 山西健司、上坂俊允、森野 佳生、朝岡亮、村田博史
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-215556
  • Filing Date: 2016-11-02
• [Patent(Industrial Property Rights)] 視野検査装置 (2015)
  • Inventor(s): 朝岡亮
  • Industrial Property Rights Holder: 朝岡亮
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-28