Nucleic acid-based drug for corneal opacities

• Project/Area Number: 26462680
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: The University of Tokyo
• Principal Investigator: USUI TOMOHIKO 東京大学, 医学部附属病院, 准教授 (80282557)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 角膜 / 核酸医薬 / 血管新生

Outline of Final Research Achievements

Nucleic acid drug is expected as new therapeutic tool for various diseases because of its high safety and economical aspects. Recently, we generate a single-stranded proline-modified short hairpin ribonucleric acid interference (RNAi) and micro-RNA (mi-RNA) molecule that is carried in a lipid nano-particle for topical application. This agent can penetrate all layers of the cornea and successfully inhibit the expressions of target molecules. This modified nucleic acid agent will be a new topical formulation for use against corneal diseases.

Research Products

• [Journal Article] 角膜の透明性を守る為に (2016)
  • Author(s): 臼井智彦
  • Journal Title: 日本眼科学会雑誌 Volume: 120 Pages: 246-263
  • Peer Reviewed / Open Access
• [Journal Article] Topical administration of angiopoietin-like protein 2 RNAi-loaded lipid nanoparticles suppresses corneal neovascularization (2016)
  • Author(s): Taketani Y et al
  • Journal Title: Mol Ther Nucleic Acids Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] MicroRNA-29bによる角膜血管新生、線維化抑制の検討 (2016)
  • Author(s): 竹渓友佳子、臼井智彦、神川あずさ、豊野哲也ほか
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-08
• [Presentation] 核酸医薬を用いた角膜疾患治療 (2016)
  • Author(s): 臼井智彦
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
  • Invited
• [Presentation] 角膜の透明性を守る為に (2015)
  • Author(s): 臼井智彦
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-15 – 2015-04-19
  • Invited
• [Patent(Industrial Property Rights)] PCT (2016)
  • Inventor(s): 臼井智彦他
  • Industrial Property Rights Holder: 臼井智彦他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-04-15
  • Overseas