Can ocular stiffness be a risk for glaucoma?

• Project/Area Number: 26462688
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hiroshima University
• Principal Investigator: Kiuchi Yoshiaki 広島大学, 医歯薬保健学研究院(医), 教授 (40214738)
• Co-Investigator(Kenkyū-buntansha): 竹中 丈二 広島大学, 病院(医), 講師 (70526194)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 緑内障 / 危険因子 / 眼球硬性 / 眼圧測定 / 角膜バイオメカニクス / 緑内障危険因子

Outline of Final Research Achievements

The purpose of this project is to clarify the effect of ocular biomechanics on the progression of the glaucomatous optic neuropathy. Corneal hysteresis obtained by Ocular Response Analyzer is related to the ocular biomechanical parameter with Corvis ST. The progression speed of glaucomatous damage is related to the parameters by Corvis ST. Adding the Corneal hysteresis to Corvis parameters can enhance the prediction ability of glaucomatous damage progression.

Research Products

• [Journal Article] Ocular Biomechanics Study Group.Cataract surgery causes biomechanical alterations to the eye detectable by Corvis ST tonometry. (2017)
  • Author(s): Kato Y, Nakakura S, Asaoka R, Matsuya K, Fujio Y, Kiuchi Y; Ocular Biomechanics Study Group..
  • Journal Title: PLoS One. Volume: 12 Issue: 2 Pages: e0171941-e0171941
  • DOI: 10.1371/journal.pone.0171941
  • Peer Reviewed / Open Access
• [Journal Article] A Comparison of the Corrected Intraocular Pressure Obtained by the Corvis ST and Reichert 7CR Tonometers in Glaucoma Patients. (2017)
  • Author(s): Nakao Y, Kiuchi Y, Okimoto S.
  • Journal Title: PLoS One Volume: 12 Issue: 1 Pages: e0170206-e0170206
  • DOI: 10.1371/journal.pone.0170206
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects. (2016)
  • Author(s): Matsuura M, Murata H, Nakakura S, Nakao Y, Yamashita T, Hirasawa K, Fujino Y, Kiuchi Y, Asaoka R.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 414-414
  • DOI: 10.1038/s41598-017-00345-y
  • Peer Reviewed / Open Access
• [Journal Article] Matsuura M, Hirasawa K, Murata H, Yanagisawa M, Nakao Y, Nakakura S, Kiuchi Y, Asaoka R. (2016)
  • Author(s): Matsuura M, Hirasawa K, Murata H, Yanagisawa M, Nakao Y, Nakakura S, Kiuchi Y, Asaoka R
  • Journal Title: PLoS One Volume: 11 Issue: 8 Pages: e0161742-e0161742
  • DOI: 10.1371/journal.pone.0161742
  • Peer Reviewed / Open Access
• [Journal Article] A Pilot Evaluation Assessing the Ease of Use and Accuracy of the New Self/Home-Tonometer IcareHOME in Healthy Young Subjects (2016)
  • Author(s): Noguchi A, Nakakura S, Fujio Y, Fukuma Y, Mori E, Tabuchi H, Kiuchi Y
  • Journal Title: J Glaucoma. Volume: 25 Issue: 10 Pages: 835-841
  • DOI: 10.1097/ijg.0000000000000457
  • Peer Reviewed
• [Journal Article] 緑内障のバイオメカニクス (2015)
  • Author(s): 木内良明
  • Journal Title: 日本の眼科 Volume: 7 Pages: 859-864
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intraocular Pressure Outcomes and Risk Factors for Failure in the Collaborative Bleb-Related Infection Incidence and Treatment Study (2015)
  • Author(s): Sugimoto Y, Mochizuki H, Ohkubo S, Higashide T, Sugiyama K, Kiuchi Y
  • Journal Title: Ophthalmology Volume: 122(11) Issue: 11 Pages: 2223-2233
  • DOI: 10.1016/j.ophtha.2015.06.038
  • Peer Reviewed
• [Journal Article] Relationship between Corvis ST Tonometry Measured Corneal Parameters and Intraocular Pressure, Corneal Thickness and Corneal Curvature (2015)
  • Author(s): Asaoka R, Nakakura S, Tabuchi H, Murata H, Nakao Y, Ihara N, Rimayanti U, Aihara M, Kiuchi Y
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: e0140385-e0140385
  • DOI: 10.1371/journal.pone.0140385
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Morphological features and important parameters of large optic discs for diagnosing glaucoma (2015)
  • Author(s): Okimoto S, Yamashita K, Shibata T, Kiuchi Y
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0118920-e0118920
  • DOI: 10.1371/journal.pone.0118920
  • Peer Reviewed / Open Access
• [Journal Article] Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy. (2015)
  • Author(s): Latief MA, Chikama T, Ko JA, Kiuchi Y, Sakaguchi T, Obana A.
  • Journal Title: Mol Vis. Volume: 21 Issue: 1 Pages: 532-537
  • DOI: 10.1007/s10103-014-1681-6
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 正常眼圧緑内障のバイオメカニクス (2015)
  • Author(s): 木内良明
  • Journal Title: 日本の眼科 Volume: 86
  • Peer Reviewed
• [Journal Article] Ocular Surface Displacement with and without Contact Lenses during Non-Contact Tonometry (2014)
  • Author(s): Rimayanti U., Kuchi Y., Umemura S., Takenaka J., Mochizuki H., and Kaneko M
  • Journal Title: PLOS ONE Volume: 9 Issue: 4 Pages: 1-7
  • DOI: 10.1371/journal.pone.0096066
  • Peer Reviewed / Open Access
• [Presentation] Glaucoma and Ocular surface (2016)
  • Author(s): Yoshiaki Kiuchi
  • Organizer: The 116th Annual meeting of The Korean Ophthalmological Society
  • Place of Presentation: Gyeonggi-do （韓国）
  • Year and Date: 2016-11-04
  • Int'l Joint Research / Invited
• [Presentation] Approaches for over filtering and leaking blebs (2016)
  • Author(s): Yoshiaki KIuchi
  • Organizer: 2016 3rd Asia-Pacific Glaucoma Congress
  • Place of Presentation: Chiang Mai （タイ）
  • Year and Date: 2016-07-14
  • Int'l Joint Research / Invited
• [Presentation] Effect of cataract surgery on the biomechanical property of the cornea. (2016)
  • Author(s): Kiuchi Y, Nakao Y, Ihara N, Nakakura S, Asaoka R, Aihara M
  • Organizer: ARVO2016 Annual Meeting
  • Place of Presentation: Seattle （米国）
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Effect of cataract surgery on the biomechanical property of the cornea (2016)
  • Author(s): Kiuchi Y, Nakao Y, Ihara N, Noguchi A, Nakakura S, et al
  • Organizer: ARVO anual meeting
  • Place of Presentation: シアトル ワシントン （米国）
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] 角膜生体力学を計測可能な眼圧計による角膜性状と眼圧の相互作用 (2016)
  • Author(s): 木内良明
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
  • Invited
• [Presentation] 白内障手術が角膜生体力学特性に及ぼす影響 (2016)
  • Author(s): 野口明日香、 中倉俊祐、 藤尾有希、 森 悦子、 福間保子、 松谷香奈恵、 小林由依、 永富のぞみ、 田淵仁志、 朝岡 亮、 中尾善隆、 木内良明
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Presentation] Ocular Surface Changes Induced by Ocular Hypotensive Eye Drops (2015)
  • Author(s): Kiuchi Y
  • Organizer: 台湾日本ジョイントミーティング
  • Place of Presentation: 台北 （中華民国）
  • Year and Date: 2015-11-28
  • Int'l Joint Research / Invited
• [Presentation] Demographic factors of the eye and Corvis St parameters (2015)
  • Author(s): Kiuchi Y,Nakamura S,Nakano Y,Tabuchi H,Rimayanti U
  • Organizer: XXXIII Congress of the ESCRS
  • Place of Presentation: バルセロナ スペイン
  • Year and Date: 2015-09-05
  • Int'l Joint Research
• [Presentation] CORNEAL BIOMECHANICAL PARAMETERS IN SUBJECTS WITH OPEN ANGLE AND ANGLE CLOSURE (2015)
  • Author(s): Yoshiaki Kiuchi, Yoshitaka Nakao, Ulfah Rimayanti
  • Organizer: 6th World Glaucoma Congress 2015
  • Place of Presentation: Hong Kong
  • Year and Date: 2015-06-06 – 2015-06-09
• [Presentation] Corneal displacement and biomechanical parameters in glaucoma subjects with different lens conditions (2015)
  • Author(s): Ulfah Rimayanti,, Yoshiaki Kiuchi, Yoshitaka Nakao, et al
  • Organizer: ARVO 2015
  • Place of Presentation: Denver 米国
  • Year and Date: 2015-05-03 – 2015-05-07
• [Presentation] Reproducibility of optic disc evaluation in supine subjects with a laser tomographic scanner(Heidelberg Retina Tomograph Ⅱ) (2015)
  • Author(s): Kiuchi Y、Harada Y, Takenaka J
  • Organizer: ARVO imaging conference
  • Place of Presentation: デンバー コロラド （米国）
  • Year and Date: 2015-05-02
  • Int'l Joint Research
• [Presentation] 開放隅角緑内障と閉塞隅角緑内障の角膜生体力学特性の比較 (2015)
  • Author(s): 木内良明,中尾善隆 , 杉本洋輔, 井原範子, Ulfah Rimayanti
  • Organizer: 第１１９回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16 – 2015-04-19
• [Presentation] Corneal biomechanical parameters in subjects with glaucoma (2015)
  • Author(s): Kiuchi,Yoshiaki; Rimayanti, Ulfah; Nakao, Yoshitaka; Kanako, Makoto
  • Organizer: Asia ARVO 2015
  • Place of Presentation: Yokohama
  • Year and Date: 2015-02-16 – 2015-02-19
• [Presentation] 緑内障のバイオメカニクス (2014)
  • Author(s): 木内良明
  • Organizer: 第68回 日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2014-11-13 – 2014-11-16
  • Invited
• [Book] 前視野緑内障に向き合う－PPGを発見した時、どう考え管理するか－ (2016)
  • Author(s): 木内良明
  • Total Pages: 237
  • Publisher: 文光堂
• [Book] 今日の治療指針 (2016)
  • Author(s): 木内良明
  • Total Pages: 2096
  • Publisher: 医学書院
• [Book] Glaucoma Medical Diagnosis & Therapy (2015)
  • Author(s): Kiuchi y
  • Total Pages: 1201
  • Publisher: Elsevier