| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Severe ocular surface disease lost corneal and conjunctival epithelial stem cells, resulting in severe visual impairment and scar formation. We have developed cultured mucosal epithelial transplantation therapy using regenerative medicine and improved the outcome of treatment. In this study, we analyzed the survived epithelium and proved that the oral mucosal epithelium does not change to the ocular surface epithelium and maintains original cell characteristics. Furthermore, we have developed a new culturing method independent of xeno materials and cultivated epithelial sheets using nasal mucosal epithelium as other cell source. As an alternative cell source, we used nasal mucosal epithelium to generate the cultivated sheet containing goblet cells for ocular surface reconstruction.
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