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Regulation of tissue fibrosis and natural helper cells in ocular atopy

Research Project

Project/Area Number 26462698
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionJuntendo University

Principal Investigator

Murakami Akira  順天堂大学, 医学部, 教授 (90157743)

Co-Investigator(Kenkyū-buntansha) 松田 彰  順天堂大学, 医学(系)研究科(研究院), 准教授 (00312348)
堀 寛爾  順天堂大学, 医学部, 助教 (30529227)
Co-Investigator(Renkei-kenkyūsha) NAKAE Susumu  東京大学, 医科学研究所, 准教授 (60450409)
Research Collaborator ASADA Yosuke  順天堂大学, 医学部, 助教
IWAMOTO Satoshi  順天堂大学, 医学部, 助教
SUGITA Jobu  順天堂大学, 医学部, 助手
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsナチュラルヘルパー細胞 / 涙腺 / アレルギー性結膜炎 / 組織線維化 / 自然リンパ球 / アトピー性炎症 / アトピー性皮膚炎 / 緑内障 / 白内障 / 網膜剥離
Outline of Final Research Achievements

In previous study we found abundant distribution of natural helper cell (NH cell) in lacrimal gland. We investigated the roles of NH cells for the ocular surface pathology by removing extra orbital lacrimal gland tissue in mouse, and then made ragweed induced experimental allergic conjunctivitis. We found that lacrimal gland excision did not affect the number of infiltrated eosinophils. On the other hand lacrimal gland excision did induced strong corneal inflammation especially in IL-33 knockout mice. Our results suggested that NH cells and IL-33 may contribute to the homeostasis of ocular surface.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes2016

    • Author(s)
      Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T.
    • Journal Title

      J Immunol

      Volume: 196 Issue: 9 Pages: 3559-3569

    • DOI

      10.4049/jimmunol.1500717

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epicutaneous allergic sensitization by cooperation between allergn protease activity and mechanical skin barrier damage in mice2016

    • Author(s)
      Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.
    • Journal Title

      J Invest Dermatol

      Volume: 136 Issue: 7 Pages: 1408-1417

    • DOI

      10.1016/j.jid.2016.02.810

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of epithelial cell-derived type 2 initiating cytokines in experimental allergic conjunctivitis.2015

    • Author(s)
      Asada Y, Nakae S, Ishida W, Hori K, Sugita J et al.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 56 Issue: 9 Pages: 5194-5202

    • DOI

      10.1167/iovs.15-16563

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] アトピー性疾患の組織線維化2017

    • Author(s)
      松田 彰
    • Organizer
      第121回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Interleukin(IL)-33 and Thymic Stromal Lymphopoietin (TSLP), but not IL-25, induced Allergic Conjunctivitis in Mouse Models Papain-Induced Conjunctivitis.2014

    • Author(s)
      Yosuke Asada, Akira Matsuda, Kanji Hori, Satoshi Iwamoto, Nobuyuki Ebihara, Akira Murakami, Susumu Nakae
    • Organizer
      Annual meeting for the Association of Research in Vision and Ophthalmology
    • Place of Presentation
      Orlando,FL,USA
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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