| Project/Area Number |
26462698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松田 彰 順天堂大学, 医学(系)研究科(研究院), 准教授 (00312348)
堀 寛爾 順天堂大学, 医学部, 助教 (30529227)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
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| Research Collaborator |
ASADA Yosuke 順天堂大学, 医学部, 助教
IWAMOTO Satoshi 順天堂大学, 医学部, 助教
SUGITA Jobu 順天堂大学, 医学部, 助手
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナチュラルヘルパー細胞 / 涙腺 / アレルギー性結膜炎 / 組織線維化 / 自然リンパ球 / アトピー性炎症 / アトピー性皮膚炎 / 緑内障 / 白内障 / 網膜剥離 |
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| Outline of Final Research Achievements |
In previous study we found abundant distribution of natural helper cell (NH cell) in lacrimal gland. We investigated the roles of NH cells for the ocular surface pathology by removing extra orbital lacrimal gland tissue in mouse, and then made ragweed induced experimental allergic conjunctivitis. We found that lacrimal gland excision did not affect the number of infiltrated eosinophils. On the other hand lacrimal gland excision did induced strong corneal inflammation especially in IL-33 knockout mice. Our results suggested that NH cells and IL-33 may contribute to the homeostasis of ocular surface.
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