| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study is to regenerate the retina after injury. Although genes involved in eye development very similar to those of other animals, the regenerative ability of retina differs between mammal and fish. We guessed that one of the cause of inability to regenerate is epigenetic modification that regulate genes expression. We found that immature retina has the regenerative ability of retina after the damage and also found this ability is gradually lost until the retinal maturation. Furthermore, we elucidated that genes of mature Müller cells that is the soure of retinal regeneration were strongly repressed by epigenetic modification. Our results indicated the possibility that this repression will be removed.
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