Analysis of atrophy of retinal ganglion cells in homonymous hemianopia using optical coherence tomography
| Project/Area Number |
26462703
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MIKI ATSUSHI 川崎医科大学, 医学部, 教授 (90447607)
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| Co-Investigator(Kenkyū-buntansha) |
山下 力 川崎医療福祉大学, 医療技術学部, 講師 (00515877)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Ryoji 川崎医療福祉大学, 医療技術学部, 教授 (40111710)
TANZAWA Keiichi 川崎医療福祉大学, 医療技術学部, 助教 (30717096)
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| Research Collaborator |
ARAKI Syunsuke
GOTO Katsutoshi
TAKIZAWA Go
MAEDA Fumiatsu
Liu Chia-Shang J.
YAOEDA Kiyoshi
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 同名半盲 / 網膜神経節細胞 / 光干渉断層計 / 視神経萎縮 / 経シナプス変性 / 後頭葉 / 脳梗塞 / 網膜神経線維層 / 逆行性経シナプス変性 / 神経節細胞複合体厚 / 視神経乳頭周囲網膜神経線維層厚 / 後大脳動脈 / 対光反射 / 外側膝状体 |
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| Outline of Final Research Achievements |
It has been believed that the damage does not occur in the retina ganglion cells (RGCs) in patients with homonymous hemianopia due to occipital lesions. However, we found that significant thinning was seen in the inner retinal layer corresponding to the affected hemifield within a few years after occipital infarction. The thinning is significantly correlated with time elapsed and is estimated to be progressive over several years. Interestingly, the thinning is remarkable in the central retina. Although the retinal thinning could be attributed to transsynaptic retrograde degeneration of RGC, the direct effect from the brain lesion on the anterior visual pathway could not be excluded. Pupillary hemihypokinesia is another phenomenon in occipital hemianopia that cannot be explained by the classical theory of pupillary light reflex (PLR). Therefore, for elucidation of these mechanisms, we plan to investigate the relationship between the location of the lesions and retinal thinning or PLR.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] Retinal ganglion cell atrophy in homonymous hemianopia due to acquired occipital lesions observed using Cirrus high-definition OCT.2016
Author(s)
Yamashita T, Miki A, Goto K, Araki S, Takizawa G, Ieki Y, Kiryu J, Iguchi Y, Kimura K, Yagita Y, Tabuchi A.
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Journal Title
Journal of Ophthalmology
Volume: 2016
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 序論2014
Author(s)
三木淳司
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Journal Title
Neuro-Ophthalmology Japan
Volume: 31
Issue: 2
Pages: 143-143
DOI
NAID
ISSN
0289-7024, 2188-2002
Related Report
Open Access
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[Presentation] 視交叉症候群における乳頭周囲網膜神経線維層厚, 乳頭形態と耳側半盲との関連2016
Author(s)
後藤克聡, 三木淳司, 山下力, 荒木俊介, 瀧澤剛, 平木陽子, 瀬戸口義尚, 家木良彰, 桐生純一, 宇野昌明
Organizer
第57回日本視能矯正学会
Place of Presentation
大阪国際会議場（大阪市）
Related Report
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[Presentation] 弱視の病態2015
Author(s)
三木淳司
Organizer
第69回日本臨床眼科学会
Place of Presentation
名古屋国際会議場（愛知県・名古屋市）
Year and Date
2015-10-23
Related Report
Invited
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[Presentation] 弱視の視路の病態研究2015
Author(s)
三木淳司
Organizer
第23回広島小児眼科懇話会
Place of Presentation
広島国際会議場（広島県・広島市）
Year and Date
2015-10-04
Related Report
Invited
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[Presentation] 外側膝状体以降の視路病変による同名半盲におけるRAPDxを用いたRAPDの定量2014
Author(s)
瀧澤剛, 三木淳司, 後藤克聡, 荒木俊介, 前田史篤, 丹沢慶一, 山下力, 春石和子, 家木良彰, 桐生純一, 田淵昭雄, 八百枝潔
Organizer
第52回日本神経眼科学会総会
Place of Presentation
幕張メッセ（千葉）
Year and Date
2014-12-12
Related Report
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[Presentation] 外側膝状体以降の視路病変による同名半盲におけるRAPDx2014
Author(s)
瀧澤剛, 三木淳司, 後藤克聡, 荒木俊介, 前田史篤, 丹沢慶一, 山下力, 春石和子, 家木良彰, 桐生純一, 田淵昭雄, 八百枝潔
Organizer
第62回川崎医科大学眼科学術会
Place of Presentation
ホテルグランヴィア岡山（岡山）
Year and Date
2014-12-07
Related Report
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[Presentation] 同名半盲患者における網膜神経節細胞複合体厚significance map 異常領域面積評価2014
Author(s)
山下力, 三木淳司, 田淵昭雄, 金子佳乃子, 亀山明里, 黒田菜月, 樽崎由依, 後藤克聡, 荒木俊介, 春石和子, 家木良彰, 桐生純一
Organizer
第68回日本臨床眼科学会
Place of Presentation
神戸ポートピアホテル・神戸国際展示場（神戸）
Year and Date
2014-11-14
Related Report
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