Pathophysiology of gastroesophageal reflux in neurologically impaired children
Project/Area Number |
26462706
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatric surgery
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 胃食道逆流 / GER / 胃排出遅延 / 食道インピーダンスpHモニタリング / 酸性GER / 非酸性GER / 重症心身障がい児 / 食道インピーダンスpHモニタリング / 胃食道逆流症 / 酸性胃食道逆流 / 非酸性胃食道逆流 / 食道インピーダンスpHモニタリグ / 胃排出能 / 六君子湯 / 胃瘻 / 噴門形成術 / gastroesophageal reflux / impedance pH monitoring / gastric emptying / rikkunshito / gastrostomy / neurological impairment |
Outline of Final Research Achievements |
Neurologically impaired(NI) patients showed a wide range of gastric emptying rates without any significant causal relationship between delayed gastric emptying and gastroesophageal reflux(GER). The results suggest that the proximal gastric accommodation, which is caused by adaptive gastric relaxation, is a more important factor for controlling GER than the acceleration of gastric emptying. There was an increase in acid GER in NI pediatric patients with abnormal GER, whereas acid and nonacid GER were comparable in NI pediatric patients without abnormal GER. Although the underlying mechanism of our findings could not be fully explained, physiologically appropriate therapeutic approaches for GER disease in NI patents should include the reduction of acid GER to that of nonacid GER rather than the complete prevention of all GER.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Long-term outcomes of four patients with tracheal agenesis who underwent airway and esophageal reconstruction.2015
Author(s)
Tazuke Y, Okuyama H, Uehara S, Ueno T, Nara K, Yamanaka H, Kawahara H, Kubota A, Usui N, Soh H, Nomura M, Oue T, Sasaki T, Nose S, Saka R
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Journal Title
Journal of Pediatric Surgery
Volume: 50
Issue: 12
Pages: 2009-2011
DOI
Related Report
Peer Reviewed
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[Journal Article] Parental Nutrition-Associated Liver Disease in Extremely Low Birth Weight Infants with Intestinal Disease.2015
Author(s)
Hirano K, Kubota A, Nakayama M, Kawahara H, Yoneda A, Tazuke Y, Tani G, Ishii T, Goda T, Umeda S, Hirno S, Shiraishi J, Kitajima H.
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Journal Title
Pediatr Int.
Volume: 57
Issue: 4
Pages: 677-81
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Efficacy and safety of strong acid electrolyzed water for peritoneal lavage to prevent surgical site infection in patients with perforated appendicitis2015
Author(s)
Kubota A, Goda T, Tsuru T, Yonekura T, Yagi M, Kawahara H, Yoneda A, Tazuke Y, Tani G, Ishii T, Umeda S, Hirano K
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Journal Title
Surgery Today
Volume: 45
Issue: 7
Pages: 876-879
DOI
Related Report
Peer Reviewed
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[Journal Article] Pediatric chronic intestinal pseudo-obstruction is a rare, serious, and intractable disease: A report of a nationwide survey in Japan.2014
Author(s)
Muto M, Matsufuji H, Tomomasa T, Nakajima A, Kawahara H, Ida S, Ushijima K, Kubota A, Mushiake S, Taguchi T.
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Journal Title
J Pediatr Surg
Volume: 49(12)
Issue: 12
Pages: 1799-1803
DOI
Related Report
Peer Reviewed / Open Access
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