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Evaluation of FOXM1 and related protein expression as target molecule in refractory pediatric malignant soft tissue tumor

Research Project

Project/Area Number 26462708
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

KUDA MASAAKI  九州大学, 医学研究院, 助教 (40381230)

Co-Investigator(Kenkyū-buntansha) 田口 智章  九州大学, 医学研究院, 教授 (20197247)
木下 義晶  九州大学, 大学病院, 准教授 (80345529)
宗崎 良太  九州大学, 大学病院, 助教 (10403990)
孝橋 賢一  九州大学, 医学研究院, 講師 (10529879)
三好 きな  九州大学, 医学研究院, 助教 (20621709)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords小児悪性軟部腫瘍 / FOXM1 / 横紋筋肉腫 / 滑膜肉腫 / 治療標的分子 / Forkhead box M1 (FOXM1) / VEGF / 平滑筋肉腫 / 悪性黒色腫 / 血管肉腫 / 血管新生 / 分子標的療法
Outline of Final Research Achievements

Pediatric malignant soft tissue tumor has a poor prognosis, and a new therapeutic target is desired. Currently, Forkhead box M1 (FOXM1) is one of the most notable molecules as a new therapeutic target in major malignant tumors.
We evaluated FOXM1 expression in 92 patients with rhabdomyosarcoma (RMS) and 106 synovial sarcoma (SS) among pediatric malignant soft tissue tumors. We showed that FOXM1 expression is associated with poor prognosis. In RMS, FOXM1 correlated with VEGF expression and angiogenesis. In cDNA microarray analysis of SS cases, we showed that cell cycle related gene expression correlates with FOXM1 expression. We showed that FOM1 inhibition could be a new treatment option in studies of cell lines of each tumor.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 9 results,  Acknowledgement Compliant: 5 results) Presentation (6 results) (of which Invited: 1 results)

  • [Journal Article] Prognostic Significance of FOXM1 Expression and Antitumor Effect of FOXM1 Inhibition in Synovial Sarcomas2016

    • Author(s)
      Maekawa A, Kohashi K, Kuda M, Iura K, Ishii T, Endo M, Nakatsura T, Iwamoto Y, Oda Y
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 511-511

    • DOI

      10.1186/s12885-016-2542-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Significance of Forkhead Box M1 (FOXM1) Expression and Antitumor Effect of FOXM1 Inhibition in Angiosarcoma.2016

    • Author(s)
      Ito T, Kohashi K, Yamada Y, Iwasaki T, Maekawa A, Kuda M, Hoshina D, Abe R, Furue M, Oda Y.
    • Journal Title

      J Cancer

      Volume: Apr 27;7(7) Issue: 7 Pages: 823-30

    • DOI

      10.7150/jca.14461

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of Forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in melanoma.2016

    • Author(s)
      Ito T, Kohashi K, Yamada Y, Maekawa A, Kuda M, Furue M, Oda Y
    • Journal Title

      Histopathology

      Volume: 69(1) Issue: 1 Pages: 63-71

    • DOI

      10.1111/his.12909

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FOXM1 expression in rhabdomyosarcoma: a novel prognostic factor and therapeutic target.2016

    • Author(s)
      Kuda M, Kohashi K, Yamada Y, Maekawa A, Kinoshita Y, Nakatsura T, Iwamoto Y, Taguchi T, Oda Y.
    • Journal Title

      Tumour Biol.

      Volume: 37 Issue: 4 Pages: 5213-23

    • DOI

      10.1007/s13277-015-4351-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of Forkhead box M1 in soft tissue leiomyosarcoma: Clinicopathologic and in vitro study using a newly established cell line.2016

    • Author(s)
      Maekawa A, Kohashi K, Setsu N, Kuda M, Iura K, Ishii T, Matsunobu T, Nakatsura T, Iwamoto Y, Oda Y.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 1 Pages: 95-102

    • DOI

      10.1111/cas.12846

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three-dimensional liver model based on preoperative CT images as a tool to assist in surgical planning for hepatoblastoma in a child.2015

    • Author(s)
      Souzaki R, Kinoshita Y, Ieiri S, Hayashida M, Koga Y, Shirabe K, Hara T, Maehara Y, Hashizume M, Taguchi T.
    • Journal Title

      Pediatr Surg Int.

      Volume: 31 Issue: 6 Pages: 593-593

    • DOI

      10.1007/s00383-015-3709-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative surgical simulation of laparoscopic adrenalectomy for neuroblastoma using a three-dimensional printed model based on preoperative CT images.2015

    • Author(s)
      Souzaki R, Kinoshita Y, Ieiri S , Kawakubo N, Obata S, Jimbo T, Koga Y, Hashizume M, Taguchi T.
    • Journal Title

      J Pediatr Surg.

      Volume: 50 Issue: 12 Pages: 2112-2112

    • DOI

      10.1016/j.jpedsurg.2015.08.037

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ERG and SALL4 expressions in SMARCB1/INI1-deficient tumors: a useful tool for distinguishing epithelioid sarcoma from malignant rhabdoid tumor.2015

    • Author(s)
      Kohashi K, Yamada Y, Hotokebuchi Y; Yamamoto H, Taguchi T, Iwamoto Y, Oda Y
    • Journal Title

      Hum Pathology

      Volume: 46(2) Issue: 2 Pages: 225-230

    • DOI

      10.1016/j.humpath.2014.10.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glypican 3 Expression in Pediatric Malignant Solid Tumors.2015

    • Author(s)
      Kinoshita Y, Tanaka S, Souzaki R, Miyoshi K, Kohashi K, Oda Y, Nakatsura T, Taguchi T.
    • Journal Title

      Eur J Pediatr Surg.

      Volume: 25 Issue: 01 Pages: 138-44

    • DOI

      10.1055/s-0034-1393961

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic potential of mesenchymal stem cell transplantation in a nitrofen-induced congenital diaphragmatic hernia rat model.2014

    • Author(s)
      Yuniartha R, Alatas FS, Nagata K, Kuda M, Yanagi Y, Esumi G, Yamaza T, Kinoshita Y, Taguchi T.
    • Journal Title

      Pediatr Surg Int

      Volume: 30(9) Issue: 9 Pages: 907-914

    • DOI

      10.1007/s00383-014-3576-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Close correlation between CXCR4 and VEGF expression and frequent CXCR7 expression in rhabdomyosarcoma2014

    • Author(s)
      Miyoshi K, Kohashi K, Fushimi F, Yamamoto H, Taguchi T, Iwamoto Y, Oda Y
    • Journal Title

      Hum Pathol

      Volume: 45(9) Issue: 9 Pages: 1900-1909

    • DOI

      10.1016/j.humpath.2014.05.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 次世代の横紋筋肉腫治療~分子標的治療からワクチン療法まで2016

    • Author(s)
      久田正昭、木下義晶、中面哲也、小田義直、田口智章
    • Organizer
      第36回 日本小児病理研究会学術集会 シンポジウム
    • Place of Presentation
      福岡市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 横紋筋肉腫におけるFOXM1発現の検討2015

    • Author(s)
      久田正昭、孝橋賢一、中面哲也、三好きな、山田裕一、山元英崇、田口智章、岩本幸英、小田義直
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 横紋筋肉腫におけるFOXM1発現の検討 Forkhead box M1 expression in rhabdomyosarcoma2015

    • Author(s)
      久田正昭、孝橋賢一、中面哲也、三好きな、山田裕一、山元英崇、田口智章、岩本幸英、小田義直
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] Expressions of Core Subunits of SWI/SNF Chromatin Comples in SMARCB1/INI1-Defficient Tumors2015

    • Author(s)
      Kohashi K, Yamamoto H, Yamada Y, Oda Y.
    • Organizer
      USCUP Annual Meeting
    • Place of Presentation
      USA, Boston, MA
    • Year and Date
      2015-03-21 – 2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 滑膜肉腫臨床検体におけるmelanoma inhibitory activity proteinの発現2014

    • Author(s)
      前川啓、孝橋賢一、井浦国生、石井武彰、高橋祐介、山田裕一、岩本幸英、小田義直
    • Organizer
      日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-17 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 隆起性皮膚線維肉腫におけるAkt/mTOR pathwayの解析2014

    • Author(s)
      佛淵由佳、山田裕一、孝橋賢一、山元英崇、古江増隆、岩本幸英、小田義直
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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