Elucidation of the pathogenesis of dyfecation/dysuria and development of novel treatment for spina bifida using animal model.
Project/Area Number |
26462715
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatric surgery
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Research Institution | Juntendo University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
宮原 克 順天堂大学, 医学(系)研究科(研究院), 研究技師 (00420844)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 二分脊椎症 / 鎖肛 / 腸管神経系 / セマフォリン3A / 虚血再灌流障害 / セマフォリン3A / 排便機能障害 / モデルマウス / 神経栄養因子 / 神経堤細胞 |
Outline of Final Research Achievements |
This study demonstrated that the abnormality of distribution of enteric nerve system (ENS) and the expression change of GDNF was observed in the intestine of the mouse model of spina bifida. In addition, in the intestinal ischemic reperfusion experiment to detect the related factors to the restoration of ENS, we obtained the correlation between semaphorin 3A and intestinal glial cells after reperfusion.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Pediatric Surgery2015
Author(s)
wanaka T, Yamataka A, Uemura S, Okuyama H, Segawa O, Nio M, Yoshizawa J, Yagi M, Ieiri S, Uchida H, Koga H, Sato M, Soh H, Take H, Hirose R, Fukuzawa H, Mizuno M, Watanabe T
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Journal Title
Asian J Endosc Surg
Volume: 8
Issue: 4
Pages: 390-407
DOI
Related Report
Peer Reviewed
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