| Project/Area Number |
26462719
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
杉藤 公信 日本大学, 医学部, 助教 (10328750)
小沼 憲祥 日本大学, 医学部, 助手 (50553103)
越永 從道 日本大学, 医学部, 教授 (70205376)
益子 貴行 日本大学, 医学部, 助手 (30526067)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 消化管穿孔 / 胎便関連性腸閉塞 / 極低出生体重児 / インドメタシン / SLIP / MO / SAG児 / プロスタグランジン / 低出生体重児 |
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| Outline of Final Research Achievements |
We analyzed clinical data of extremely low birth weight infants (ELBWI) who developed gastrointestinal disorders (SIP, MOP) on our NICU. As similar as other reports, our result indicated that MOP occurred more likely on SGA patients. We couldn’t prove our hypothesis that the etiology of SIP and MOP were related to blood flow imbalance between renal artery (RA) and superior mesenteric artery (SMA) of ELBWI. Furthermore, vascular reaction against indomethacin administration seemed to have not been significant difference between RA and SMA. We focused on the vulnerability of intestinal wall of ELBWI and compared patients intestinal wall with control (fetal intestine of 10weeks gestation). The result indicated patient’s intestinal wall thickness were as thin as 10weeks old fetal intestinal wall. This result implied that the patients who developed SIP or MOP had a potential risk factor while they were in utero.
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