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The examination about the osteoinductive activity of the biodegradable magnesium alloy

Research Project

Project/Area Number 26462724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionTohoku University

Principal Investigator

Imai Yoshimichi  東北大学, 医学系研究科, 准教授 (80323012)

Co-Investigator(Kenkyū-buntansha) 清水 良央  東北大学, 歯学研究科, 助教 (30302152)
向井 敏司  神戸大学, 先端融合研究環, 教授 (40254429)
山本 玲子  国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点 ナノバイオ部門バイオメタルグループ, グループリーダー (20343882)
Research Collaborator MIURA Chieko  東北大学, 医学系研究科, 助教
SATO Akimitsu  東北大学, 医学系研究科, 医員
SANO Yuya  東北大学, 歯学研究科, 産学官連携研究員
OIKAWA Miho  東北大学, 歯学研究科, 産学官連携研究員
ISOZAKI Shuji  (株)パイオラックスメディカルデバイス
TAKAHASHI Yasushi  (株)パイオラックスメディカルデバイス
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsマグネシウム合金 / 骨折 / 骨形成 / 生体吸収性材料 / 生体適合性 / 再建外科学 / 形成外科学
Outline of Final Research Achievements

The aim of this study was to clarify the influence of the physiological environment surrounding Mg alloys on their corrosion behaviour. A Mg-1.0Al alloy with a fine-grained structure was formed into plates using titanium (Ti) as a control. These plates were implanted into the subperiosteum in the head, subcutaneous tissue of the back, and in the muscle of the femur of rats for 1, 2 and 4 weeks. The Mg alloy was corroded fastest in the head, at an intermediate level in the back, and slowest in the femur. The insoluble salt deposition at the Mg alloy surface had no influence on the volume loss. Gas cavities formed around the Mg alloy at all implantation sites and decreased after 4 weeks. Histopathological examination revealed that the Mg alloy exhibited good biocompatibility, as was seen with Ti. In addition, vascularized fibrous capsules formed around the plates and became mature with time. The volume loss in the different anatomical locations correlated with capsule thickness.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] In vivo corrosion behaviour of magnesium alloy in association with surrounding tissue response in rats2016

    • Author(s)
      Miura C Shimizu Y Imai Y Mukai T Yamamoto A Sano Y Ikeo N Isozaki S Takahashi T Oikawa M Kumamoto H Tachi M
    • Journal Title

      Biomedical Materials

      Volume: 11 Issue: 2 Pages: 025001-025001

    • DOI

      10.1088/1748-6041/11/2/025001

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 生分解性マグネシウム合金の骨固定用デバイスへの応用 -動物実験モデルにおける 手術手技での実用性評価-2017

    • Author(s)
      三浦千絵子、佐藤顕光、今井啓道、館 正弘、清水良央、佐野 有哉、向井敏司、池尾 直子、山本玲子、磯崎 修二、高橋 泰
    • Organizer
      第27回東北大学形成外科同門会
    • Place of Presentation
      東北大学医学部臨床小講堂(宮城県・仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生分解性マグネシウム合金の ラット体内における分解挙動と組織反応2015

    • Author(s)
      三浦千絵子、佐藤顕光、今井啓道、館正弘、清水良央、佐野有哉、及川美穂、向井敏司、池尾直子、山本玲子、磯崎修二、高橋泰
    • Organizer
      第24回日本形成外科学会基礎学術集会
    • Place of Presentation
      岩手県民会館(盛岡市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Remarks] 東北大学大学院医学系研究科 形成外科学分野

    • URL

      http://www.prs.med.tohoku.ac.jp/

    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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