Research Project
Grant-in-Aid for Scientific Research (C)
Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are required to prevent the development of sepsis. In the present study, we demonstrated that hyperglycemia induces skin barrier dysfunction with alterations of epidermal integrity, using non-wounded skin of type 1 diabetic mice. Disrupted homeostasis in the non-wounded skin could be the underlying mechanisms of non-healing diabetic skin complications.
All 2018 2017 2016 2015 2014
All Journal Article (9 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 7 results, Open Access: 4 results, Acknowledgement Compliant: 3 results) Presentation (42 results) (of which Invited: 7 results)
形成外科
Volume: 1 Pages: 100-107
40021438415
Molecular Therapy-Nucleic Acids
Volume: 11 Pages: 203-215
10.1016/j.omtn.2018.02.007
Plos One
Volume: 11 Issue: 11 Pages: e0166215-e0166215
10.1371/journal.pone.0166215
Medical Science Digest
Volume: 42 Pages: 5-5
Volume: 42(6) Pages: 5-6
Biochemical and Biophysical Research Communications
Volume: - Issue: 4 Pages: 695-701
10.1016/j.bbrc.2015.04.094
PLoS ONE
Volume: 10 Issue: 4 Pages: e0122458-e0122458
10.1371/journal.pone.0122458
FEBS letters.
Volume: 588 Issue: 6 Pages: 1080-1086
10.1016/j.febslet.2014.02.030
Congenital Anomalies
Volume: 54(2) Pages: 69-76
