Mechanism of diabetic complications in the skin
| Project/Area Number |
26462730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Okano Junko 滋賀医科大学, 医学部, 准教授 (50447968)
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| Co-Investigator(Kenkyū-buntansha) |
小島 秀人 滋賀医科大学, 医学部, 教授 (00225434)
森本 尚樹 関西医科大学, 医学部, 准教授 (40378641)
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| Co-Investigator(Renkei-kenkyūsha) |
Morimoto Naoki 関西医科大学, 医学部, 准教授 (40378641)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病性難治性潰瘍 / バリア機能 / ホメオスタシス / 糖尿病マウスモデル / 糖尿病 / 皮膚 / 難治性潰瘍 / 糖尿病マウス / 皮膚難治潰瘍 / 骨髄細胞 / モデルマウス / 表皮細胞 / 皮膚壊疽潰瘍 / 創傷治癒 / ランゲルハンス細胞 |
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| Outline of Final Research Achievements |
Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are required to prevent the development of sepsis. In the present study, we demonstrated that hyperglycemia induces skin barrier dysfunction with alterations of epidermal integrity, using non-wounded skin of type 1 diabetic mice. Disrupted homeostasis in the non-wounded skin could be the underlying mechanisms of non-healing diabetic skin complications.
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Report
(5 results)
Research Products
(51 results)
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[Journal Article] Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation2015
Author(s)
Okano J, Kojima H, Katagi M, Nakae Y, Terashima T, Nakagawa T, Kurakane T, Okamoto N, Morohashi K, Maegawa H, Udagawa J
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Journal Title
Biochemical and Biophysical Research Communications
Volume: -
Issue: 4
Pages: 695-701
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Erythropoietin receptor antagonist suppressed ectopic hemoglobin synthesis in xenografts of HeLa cells to promote their destruction.2015
Author(s)
Yasuda, Y., Fujita, M., Koike, E., Obata, K., Shiota, M., Kotani, Y., Musha, T., Tsuji-Kawahara, S., Satou, T., Masuda, S, Okano, J., Yamasaki, H., Okumoto, K., Uesugi, T., Nakao, S.,Hoshiai, H. and Mandai, M.
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Journal Title
PLoS ONE
Volume: 10
Issue: 4
Pages: e0122458-e0122458
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy.2014
Author(s)
Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H
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Journal Title
FEBS letters.
Volume: 588
Issue: 6
Pages: 1080-1086
DOI
Related Report
Peer Reviewed
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[Presentation] Circadian Rhythm in Skin2015
Author(s)
Morohashi K, Okano J, Kojima H, Katagi M, Nakae Y, Terashima T, Udagawa J
Organizer
第１２０回日本解剖学会総会・全国学術集会 第９２回日本生理学会大会
Place of Presentation
兵庫県（神戸）
Year and Date
2015-03-21 – 2015-03-23
Related Report
Invited
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