| Project/Area Number |
26462732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
成瀬 恵治 岡山大学, 医歯薬学総合研究科, 教授 (40252233)
徳山 英二郎 岡山大学, 大学病院, 助教 (90379785)
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| Research Collaborator |
TAKAHASHI Ken 岡山大学, 医歯薬学総合研究科 システム生理学, 助教 (50432258)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | メカノメディスン / human skin equivalent / 伸展培養 / 基底膜 / 細胞間interaction / 3次元全層培養皮膚 |
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| Outline of Final Research Achievements |
In this study, we developed systems that enable application of stretch stimuli to HSEs during formation. Consequently, we found that in the ST group, the epidermal layer is thicker than NST group. Furthermore, synthesis of basement membrane proteins and deposition in the basal layer are increased; therefore, a more developed basement membrane is formed. Further research using this system may elucidate effects of stretching on skin properties and wound healing. In addition, application to an in vitro model of a hypertrophic scar is also expected.
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