Elucidation of immune response by Th17/Treg in keloid and application of new therapy

• Project/Area Number: 26462738
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Nippon Medical School
• Principal Investigator: MURAKAMI MASAHIRO 日本医科大学, 医学部, 准教授 (00239500)
• Co-Investigator(Kenkyū-buntansha): 土佐 眞美子 日本医科大学, 医学部, 講師 (30301568)
• Co-Investigator(Renkei-kenkyūsha): MINAMI SHIROU 日本医科大学, 医学研究科, 教授 (10192361)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ケロイド / IL-17 / 制御性T細胞 / Th17 / Treg / Ｔｒｅｇ / ＩＬ－１７

Outline of Final Research Achievements

We studied the Th17/Treg balance in a peripheral blood and keloid tissues. There was significant difference of Th17/Treg balance in the keloid tissues compared with control. High expression of IL17 and IL10 was found in keloid tissues compared to normal skin. Treatment of normal fibroblast with recombinant IL17 and IL10 peptide resulted in an increase in collagen synthesis. These finding highlight a potential role for Th17/Treg balance triggered by IL10 and IL17 in keloid pathogenesis and development of molecular therapy for keloid.