| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Statins (HMG-CoA reductase inhibitors) exert numerous pleiotropic effects and have been shown to attenuate ischemic injury in different rodent models of stroke. This study was conducted cardiac arrest and cardiopulmonary resuscitation (CA/CPR) in mice and tested the hypothesis that statins after CPR improves survival rate and neurological outcomes. Combined treatment with hydrophilic and lipophilic statins improved survival rate and neurobehavioral scores at 4 days after CPR. Statins also decreased inflammatory cytokines, upregulated Nitric Oxided Synthase, and attenuated brain edema and histological damages in the striatum and hippocampus. These data suggest that statins after CA/CPR would be beneficial in the post resuscitation phase via systemic pleiotropic effects including anti-inflammatory response and stabilize vascular reactivity.
|
