TEMPO-RNP is a new thrapeutic agent for acute septic models: the effect of anti-oxidants converted into the micelle

• Project/Area Number: 26462744
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: University of Tsukuba
• Principal Investigator: SHIMOJO Nobutake 筑波大学, 医学医療系, 講師 (20462210)
• Co-Investigator(Kenkyū-buntansha): 丸島 愛樹 筑波大学, 医学医療系, 講師 (40722525) ; Jesmin Subrina (JESMIN Subrina) 筑波大学, 体育系, 研究員 (60374261)
• Co-Investigator(Renkei-kenkyūsha): NGASAKI Yukio 筑波大学, 数理物質系, 教授 (90198309)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 敗血症 / 酸化ストレス / ラット / 末梢循環不全 / 再灌流障害 / 活性酸素 / 末梢循環障害 / 抗酸化ストレス療法

Outline of Final Research Achievements

We implied that landiolol ameliorated septic-induced cardiomyopathy and the survival rate in septic rats induced by lipopolysaccharide(LPS). We also reported the beneficial effects of landiolol for multiple organs in some papers and paid attention to oxidative stress in sepsis. We expected that TENPO-RNP have the therapeutic roll for sepsis, which is the agent micellized antioxidant and delivered to the focus in patients. But, we could not obtain the results and only showed its possibility.
In LPS-induced septic rats, d-ROM, the marker of oxidative stress in blood, increased compared to control rats. On the other hand, pNF-H, the marker of neural damage in blood, could elicit the mechanism and be presentative for sepsis-induced cognitive impairment.

Research Products

• [Journal Article] Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1 (2016)
  • Author(s): Yujiro Matsuishi, Subrina Jesmin, Satoru Kawano, Sakuramoto Hideaki, Nobutake Shimojo, Chishimba Nathan Mowa, Shila Akhtar, Sohel Zaedi, Tanzila Khatun, Yoshiya Tsunoda, Takumi Kiwamoto, Nobuyuki Hizawa, Yoshiaki Inoue, Taro Mizutani
  • Journal Title: Life Science Volume: 166 Pages: 27-33
  • DOI: 10.1016/j.lfs.2016.10.010
  • NAID: 120007129238
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Landiolol Hydrochloride Ameliorates Liver Injury in a Rat Sepsis Model by Down Regulating Hepatic TNF-Α (2015)
  • Author(s): Yasuyo Yoshino, Subrina Jesmin, Majedul Islam, Nobutake Shimojo, Hideaki Sakuramoto, Masami Oki, Tanzila Khatun, Masato Suda, Satoru Kawano, Taro Mizutani
  • Journal Title: Journal of Vascular Medicine & Surgery Volume: 3 Issue: 02 Pages: 194-194
  • DOI: 10.4172/2329-6925.1000194
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] THREE HOURES TREATMENT OF LANDIOLOL HYDRO- CHOLORIDE, AN ULTRA-SHORT-ACTING Β-BLOCKER, IS NOT EFFECTIVE TO REVERSE ALTERED PULMONARY ENDOTHELIN-1 SYSTEM IN ACUTE LUNG INJURY IN A RAT MODEL OF EARLY HOURS OF ENDOTOXEMIA (2015)
  • Author(s): Yujiro Mitsubishi, Subrina Jesmin, Sakuramoto Hideaki, Nobutake Shimojo, Shila Akhtar, Sohel Zaedi, Tanzila Khatun, Satoru Kawano. Taro Mizutani
  • Organizer: 2015 APS/ET-14: International Conference on Endothelin: Physiology, Pathophysiology, and Therapeutics
  • Place of Presentation: Savannah, GA, USA
  • Year and Date: 2015-09-02
  • Int'l Joint Research