| Project/Area Number |
26462744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
丸島 愛樹 筑波大学, 医学医療系, 講師 (40722525)
Jesmin Subrina (JESMIN Subrina) 筑波大学, 体育系, 研究員 (60374261)
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| Co-Investigator(Renkei-kenkyūsha) |
NGASAKI Yukio 筑波大学, 数理物質系, 教授 (90198309)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 敗血症 / 酸化ストレス / ラット / 末梢循環不全 / 再灌流障害 / 活性酸素 / 末梢循環障害 / 抗酸化ストレス療法 |
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| Outline of Final Research Achievements |
We implied that landiolol ameliorated septic-induced cardiomyopathy and the survival rate in septic rats induced by lipopolysaccharide(LPS). We also reported the beneficial effects of landiolol for multiple organs in some papers and paid attention to oxidative stress in sepsis. We expected that TENPO-RNP have the therapeutic roll for sepsis, which is the agent micellized antioxidant and delivered to the focus in patients. But, we could not obtain the results and only showed its possibility.
In LPS-induced septic rats, d-ROM, the marker of oxidative stress in blood, increased compared to control rats. On the other hand, pNF-H, the marker of neural damage in blood, could elicit the mechanism and be presentative for sepsis-induced cognitive impairment.
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