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Study regarding the establishment of cardiopulmonary resuscitation based on vasopressor dynamics in cardiopulmonary arrest

Research Project

Project/Area Number 26462746
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionGunma University

Principal Investigator

Oshima Kiyohiro  群馬大学, 大学院医学系研究科, 教授 (60361375)

Co-Investigator(Kenkyū-buntansha) 萩原 周一  群馬大学, 大学院医学系研究科, 講師 (20455992)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords心肺蘇生 / 心肺停止
Outline of Final Research Achievements

Patients with CPA transferred to our hospital were enrolled prospectively. The levels of catecholamines (Ep, NEp, and DOA) in the plasma were measured using blood samples obtained at the time of admission to our hospital. Patients were divided into two groups: the return of spontaneous circulation (ROSC)(+) group and the ROSC(-) group. The levels of these agents in the plasma and the conditions of resuscitation were compared between these two groups. In 48 patients, the cause of CPA was cardiogenic and Ep was not administered prior to admission to the hospital. The ROSC(+) and ROSC(-) groups included 14 and 34 patients, respectively. The prehospital resuscitation time was significantly shorter in the ROSC(+) group, and the levels of Ep and NEp in the plasma were significantly lower in the ROSC(+) group. Increased levels of Ep in the plasma may not be associated with the acquisition of ROSC in patients with cardiogenic CPA.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015 2014

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Can the Wish to Receive Intensive Treatment in Elderly Patients with Respiratory Tract Infection Be Predicted?2018

    • Author(s)
      Hagiwara S, Kaneko M, Aoki M, Murata M, Ichikawa Y, Nakajima J, Isshiki Y, Sawada Y, Tamura J, Oshima K
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 14 Pages: 1989-1993

    • DOI

      10.2169/internalmedicine.0155-17

    • NAID

      130007404860

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-07-15
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FDP/fibrinogen ratio reflects the requirement of packed red blood cell transfusion in patients with blunt trauma2017

    • Author(s)
      Hagiwara S, Aoki M, Murata M, Kaneko M, Ichikawa Y, Nakajima J, Isshiki Y, Sawada Y, Tamura J, Oshima K
    • Journal Title

      American Journal of Emergency Medicine

      Volume: 35 Issue: 8 Pages: 1106-1110

    • DOI

      10.1016/j.ajem.2017.03.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Significance of Strong Ion Gap for Predicting Return of Spontaneous Circulation in Patients with Cardiopulmonary Arrest.2017

    • Author(s)
      Kaneko M, Hagiwara S, Aoki M, Murata M, Nakajima J, Oshima K.
    • Journal Title

      Open Medicine (Warsaw, Poland).

      Volume: 12 Issue: 1 Pages: 33-38

    • DOI

      10.1515/med-2017-0006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does the number of emergency medical technicians affect the neurological outcome of patients with out-of-hospital cardiac arrest?2017

    • Author(s)
      Hagiwara S, Oshima K, Aoki M, Miyazaki D, Sakurai A, Tahara Y, Nagao K, Yonemoto N, Yaguchi A, Morimura N; SOS-KANTO 2012 Study Group.
    • Journal Title

      American Journal of Emergency Medicine

      Volume: 35 Issue: 3 Pages: 391-396

    • DOI

      10.1016/j.ajem.2016.11.020

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Deep Vein Thrombus Occurring Immediately After Blunt Abdominal Trauma.2016

    • Author(s)
      Oshima K, Hagiwara S, Murata M, Aoki M, Kaneko M, Niwamae N, Kurabayashi M.
    • Journal Title

      Pediatric Emergency Care

      Volume: 32 Issue: 8 Pages: 538-540

    • DOI

      10.1097/pec.0000000000000870

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of extravasation in pelvic fracture using coagulation biomarkers.2016

    • Author(s)
      Aoki M, Hagiwara S, Tokue H, Shibuya K, Kaneko M, Murata M, Nakajima J, Sawada Y, Isshiki Y, Ichikawa Y, Oshima K.
    • Journal Title

      Injury

      Volume: 47 Issue: 8 Pages: 1702-1706

    • DOI

      10.1016/j.injury.2016.05.012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Study on the priority of coronary arteriography or therapeutic hypothermia after return of spontaneous circulation in patients with out-of-hospital cardiac arrest: results from the SOS-KANTO 2012 study2016

    • Author(s)
      Hagiwara S, SOS-KANTO 2012 study group
    • Journal Title

      Internal and Emergency Medicine

      Volume: Epub ahead of print Issue: 4 Pages: 577-585

    • DOI

      10.1007/s11739-015-1378-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on the Effectiveness of Cardiopulmonary Resuscitation in Elderly Patients Presenting with Cardiopulmonary Arrest on Arrival2015

    • Author(s)
      Hagiwara S, Kaneko M, Murata M, Aoki M, Nakajima J, Kanbe M, Ohyama Y, Tamura J, Oshima K.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 15 Pages: 1859-1863

    • DOI

      10.2169/internalmedicine.54.4476

    • NAID

      130005090932

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of serum fibrin degradation products and D-dimer levels as biomarkers to predict return of spontaneous circulation in patients with cardiopulmonary arrest on arrival: comparison with acid-base balance2014

    • Author(s)
      Hagiwara S, Murata M, Kaneko M, Aoki M, Kanbe M, Ohyama Y, Tamura J, Oshima K
    • Journal Title

      Acute Medicine & Surgery

      Volume: 1 Issue: 4 Pages: 222-227

    • DOI

      10.1002/ams2.44

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The significant of the serum catecholamine concentrations on ROSC in patients with cardiac arrest.2016

    • Author(s)
      Oshima K, Hagiwara S, Murata M, Aoki M, Kaneko M, Nakajima J.
    • Organizer
      45th Critical Care Congress
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心肺停止症例に対するアドレナリン投与の意義 : 血中カテコラミン濃度からの考察2016

    • Author(s)
      大嶋清宏,萩原周一,村田将人,金子稔,中島潤,澤田悠輔,一色雄太,市川優美
    • Organizer
      第44回日本救急医学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] The priority of coronary arteriography and therapeutic hypothermia after return of spontaneous circulation in patients with out-of-hospital cardiac arrest. The result of SOS-KANTO 2012 Study2014

    • Author(s)
      Hagiwara S, Oshima K, Murata M, Aoki M, Hayashida K, Sakurai A, Nagao K, Yaguchi A, Morimura N, SOSiKANTO 2012 Study Group
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Book] 救急・集中治療最新ガイドライン2018-’192018

    • Author(s)
      岡元 和文
    • Total Pages
      440
    • Publisher
      総合医学社
    • ISBN
      9784883786602
    • Related Report
      2017 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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