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Reconstruction of pre-hospital cardiopulmonary resuscitation protocol using rSO2 monitoring

Research Project

Project/Area Number 26462753
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center (2015-2016)
Kyoto University (2014)

Principal Investigator

Nishiyama Kei  独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 研究員 (90447970)

Co-Investigator(Renkei-kenkyūsha) KOIKE Kaoru  京都大学, 医学部, 教授 (10267164)
SUZUKI Takao  京都大学, 医学部, 講師 (40328810)
SATO Norio  京都大学, 医学部, 准教授 (30409205)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心肺蘇生法 / モニタリング / 脳保護 / 心肺蘇生 / 院外心肺停止 / 脳循環 / 予後
Outline of Final Research Achievements

The cerebral hypoxemia ratio can be monitored noninvasively as brain local oxygen saturation (rSO 2). Since the rSO 2 value does not require a pulse wave, it has a major advantage that it can be measured even for patients without self-heartbeat.
We measured to 33 people. At the start of the measurement in the ambulance, the rSO 2 value was almost the lowest value, but the increase in the rSO 2 value could be measured by cardiopulmonary resuscitation. However, although there was no significant difference, it was suggested that the rSO 2 value tended to be higher in the cases with return of spontaneous circulation (ROSC), and it was suggested that achievement of ROSC greatly contributes to improvement of the cerebral circulation. Measurement of rSO2 value in out-patient cardiopulmonary arrest patients was shown to be useful for prognostic prediction, assessment of resuscitation quality, and investigation of resuscitation in special situations.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Detection of pulseless electric activity using regional cerebral saturation monitoring2015

    • Author(s)
      Kei Nishiyama, Kaoru Koike
    • Journal Title

      Resuscitation

      Volume: 93 Pages: e19-e20

    • DOI

      10.1016/j.resuscitation.2015.05.016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimated cerebral oxyhemoglobin as a useful indicator of neuroprotection in patients with post-cardiac arrest syndrome: a prospective, multicenter observational study2014

    • Author(s)
      Kei Hayashida, Kei Nishiyama, Masaru Suzuki, Takayuki Abe, Tomohiko Orita, Noritoshi Ito, Shingo Hori and et al.
    • Journal Title

      Crit Care.

      Volume: 29 Issue: 4 Pages: 500-510

    • DOI

      10.1186/s13054-014-0500-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reply to Letter: Possibility of predicting neurological outcome using regional cerebral oxygen saturation (rSO2) after cardiac arrest2014

    • Author(s)
      Kei Nishiyama
    • Journal Title

      Rsusucitation

      Volume: 85 Issue: 9 Pages: e135-e135

    • DOI

      10.1016/j.resuscitation.2014.05.014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 院外心肺停止患者におけるrSO2および長期予後から見たE-CPRの適応2017

    • Author(s)
      鵜木 崇、西山 慶、伊藤 賀敏、折田 智彦、有元 秀樹、別府 賢、阿部 充、遠藤 智之、安田 英人、長尾 健
    • Organizer
      第45回日本集中治療医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regional Cerebral Saturation Monitoring by Emergency Medical Staff for Patients with Out-of-Hospital Cardiac Arrest: Preliminary Case Series from the Pre rSO2 Study2016

    • Author(s)
      Kei Nishiyama, Kaoru Koike
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Physiological Monitoring-Guided Cardiopulmonary Resuscitation using Regional Cerebral Saturation: Preliminary Case Series from the Pre rSO2 Study2016

    • Author(s)
      Kei Nishiyama
    • Organizer
      第80回日本循環器学会学術集会 日本循環器学会委員会セッション(循環器救急医療委員会) 蘇生科学シンポジウム AHA ECC-JCSジョイントセッション
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 低体温療法は、来院時rSO2値が41%~60%の中程度低酸素脳症の患者に有効である2016

    • Author(s)
      西山 慶, 伊藤 賀敏, 辻村 有香, 有元 秀樹, 林田 敬, 折田 智彦, 鵜木 崇, 遠藤 智之, 安田 英人, 長尾 健, J-POP registry investigators
    • Organizer
      第43回日本集中治療医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Severity Assessment of Brain Damage With rSO2 monitoring for Extracorporeal Cardiopulmonary Resuscitation After Out-of-hospital Cardiac Arrest2016

    • Author(s)
      33.Takashi Unoki, Kei Nishiyama, Noritoshi Ito, Tomohiko Orita, Hideki Arimoto, Satoru Beppu, Mitsuru Abe, Tomoyuki Endo, Hideto Yasuda, Ken Nagao
    • Organizer
      American Heart Association Resuscitation Science Symposium
    • Place of Presentation
      ニューオリンズ(米国)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 院外心肺停止患者に対する救急隊員によるrSO2計測に関する研究2016

    • Author(s)
      西山 慶
    • Organizer
      第19回日本臨床救急医学会総会
    • Place of Presentation
      郡山
    • Related Report
      2016 Annual Research Report
  • [Presentation] mpact of Prehospital Advanced Care on Regional BrainOxygen Saturation at Hospital Arrival and Neurological Outcomes at 90 Days in Patients with Out-of-Hospital Cardiopulmonary Arrest2015

    • Author(s)
      Hideto Yasuda, Kei Nishiyama, Noritoshi Ito, Hideki Arimoto, Tomohiko Orita, Murai Akira, Kazuo Okuchi, Hideaki Anan, Tsuyoshi Hatada,Shinichi Ishimatsu, Michiaki Tokura, Kazuhiro Shiga, Shigeki Kushimoto, and Shingo Hori
    • Organizer
      2015 American Heart Association Resuscitation Science Symposium
    • Place of Presentation
      Orland, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 救急隊員による院外心肺停止患者へのrSO2 計測に関する研究:Prehospital rSO2 study2015

    • Author(s)
      西山 慶、佐藤 格夫、鈴木 崇生、小池 薫
    • Organizer
      第43 回日本救急医学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 心停止の転帰予測 心原性院外心肺停止患者に対する来院時rSO2値に基づいた低体温療法の適応決定についての検討2015

    • Author(s)
      西山 慶, 伊藤 賀敏, 辻村 有香, 有元 秀樹, 林田 敬, 折田 智彦, 鵜木 崇, 遠藤 智之, 安田 英人, 長尾 健, J-POP registry investigators
    • Organizer
      第18回日本脳低温療法学会学術集会
    • Place of Presentation
      高松
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 院外心肺停止患者における脳低酸素重症度および長期予後から見たE-CPR・THの適応の検討2015

    • Author(s)
      西山 慶
    • Organizer
      第8回日本蘇生科学シンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] rSO2を用いた院外心肺停止患者への脳障害の重症度評価、optimal critical careの実施に向けて2015

    • Author(s)
      西山 慶
    • Organizer
      第79回日本循環器学会学術集会 日本循環器学会 委員会セッション(循環器救急医療委員会) 蘇生科学シンポジウム AHA ECC-JCSジョイントセッション
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Severity Assessment of Brain Damage with rSO2 Monitoring for Decisions Regarding Intensive Care After Out-of-Hospital Cardiac Arrest with Presumed Cardiac Causes2014

    • Author(s)
      Nishiyama K, Ito N, Abe M, Unoki T, Endo T, Himeno H, Yamada N, Mizobuchi M, Mochizuki T, Kikuchi K, Hayashida K, Arimoto H, Orita T, Nagao K.
    • Organizer
      2014 American Heart Association Resuscitation Science Symposium
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Impact of Prehospital Advanced Care on Regional Brain Oxygen Saturation at Hospital Arrival and Neu2014

    • Author(s)
      Yasuda H, Nishiyama K, Ito N, Arimoto H, Orita T, Murai A, Okuchi K, Anan H, Hatada T, Ishimatsu S, Tokura M, Shiga K, Kushimoto S, Hori S.
    • Organizer
      2014 American Heart Association Resuscitation Science Symposium
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] rSO2を用いた心肺停止患者への脳障害の重症度評価:optimal critical careの実施に向けて2014

    • Author(s)
      西山慶, 伊藤賀敏, 折田智彦, 長尾健
    • Organizer
      第40回日本救急医学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 院外心肺停止患者の来院時rSO2に対するプレホスピタルケアの影響2014

    • Author(s)
      安田英人, 西山慶, 有元秀樹, 山田法顕, 村井映, 別府賢, 阿南英明, 久志本成樹, 長尾健
    • Organizer
      第40回日本救急医学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 院外心肺停止患者への低体温療法介入指標としての来院時rSO2値の可能性 ~多施設前向き観察研究(J-POP registry)~2014

    • Author(s)
      折田 智彦、伊藤 賀敏、西山 慶、有元 秀樹、遠藤 智之、阿南 英明、望月 俊明、奥地 一夫、長尾 健
    • Organizer
      第17回 脳低温療法学会
    • Place of Presentation
      沼津
    • Year and Date
      2014-08-01 – 2014-08-02
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Triage and Severity Assessment with rSO2 Monitoring after Out-of-Hospital Cardiac Arrest: Subgroup Analyses from J-POP registry2014

    • Author(s)
      西山 慶
    • Organizer
      第23回 日本心血管インターベンション治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-07-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 救急領域でのNIRSモニタリングの意義と有用性 Medical Science Digest2015

    • Author(s)
      時津 葉子、西山 慶
    • Total Pages
      4
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2015 Research-status Report
  • [Book] 救急医学 予後判定 (特集 救急蘇生における心拍再開後ケアの実際) -- (心拍再開後ケアの実際)2014

    • Author(s)
      西山 慶
    • Total Pages
      4
    • Publisher
      へるす出版
    • Related Report
      2014 Research-status Report
  • [Book] 治療 プライマリケアで遭遇する救急疾患 心肺停止2014

    • Author(s)
      西山 慶
    • Total Pages
      4
    • Publisher
      南山堂
    • Related Report
      2014 Research-status Report
  • [Remarks] 文部科学省科学研究費補助金研究:rSO2モニタリングを用いたプレホスピタル心肺蘇生法に対する研究

    • URL

      http://kuhp.kyoto-u.ac.jp/~qqigaku/research/images/nishiyama_update.pdf

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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