| Project/Area Number |
26462754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西村 与志郎 神戸大学, 医学部附属病院, 非常勤医師 (10566970)
植木 正明 神戸大学, 医学研究科, 医学研究員 (20213332)
冨田 修平 鳥取大学, 医学部, 教授 (00263898)
大坪 里織 神戸大学, 医学部附属病院, 助教 (10568819)
山田 克己 神戸大学, 医学部附属病院, 特命准教授 (20714645)
安藤 維洋 神戸大学, 医学部附属病院, 特定助教 (50719482)
岡田 直己 神戸大学, 医学研究科, 助教 (70403293)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低酸素症 / 100％酸素蘇生 / 空気蘇生 / 蘇生ガイドライン / TNF α / IL-1β / caspase-3 / BDNF / 脳神経障害 / 脳エリスロポイチン / 脳由来神経栄養因子 / 脳神経障害発症機序 |
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| Outline of Final Research Achievements |
The present study showed that reoxygenation with 100% oxygen after hypoxia increased inflammatory cytokines and caspase-3 mRNA expressions compared with 21% oxygen in adult mice. The present study provides some insight as to why 100% oxygen has harmful effects on adult brain after hypoxia as well as neonatal brain. In the clinical situation, the oxygen concentration after hypoxia might affect neurological outcomes in adult.
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