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Analysis of HIF-1 mediated energy metabolism during septic multiple organ dysfunction syndrome

Research Project

Project/Area Number 26462759
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionYokohama City University

Principal Investigator

YAMAGUCHI Osamu  横浜市立大学, 附属病院, 准教授 (20174609)

Co-Investigator(Kenkyū-buntansha) 東條 健太郎  横浜市立大学, 医学部, 助教 (80737552)
柳 大介  横浜市立大学, 附属市民総合医療センター, 助教 (80638586)
倉橋 清泰  横浜市立大学, 附属市民総合医療センター, 准教授 (50234539)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords敗血症 / 臓器不全 / 低酸素誘導性因子 / 敗血症性臓器不全 / 敗血症性多臓器不全
Outline of Final Research Achievements

We measured HIF-1α protein levels and ATP concentrations in the lung tissues from septic mice. At the early stage, HIF-1α protein and ATP levels were increased. On the other hand, HIF-1α protein levels returned to the control level and ATP concentrations were decreased in the lung tissues at the late stage.
These observations suggest that modulation of HIF-1 might have therapeitic effects against septic mulitiple organ dysfunction syndrome through the improvement of energy metabolism.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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