| Project/Area Number |
26462759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
東條 健太郎 横浜市立大学, 医学部, 助教 (80737552)
柳 大介 横浜市立大学, 附属市民総合医療センター, 助教 (80638586)
倉橋 清泰 横浜市立大学, 附属市民総合医療センター, 准教授 (50234539)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 敗血症 / 臓器不全 / 低酸素誘導性因子 / 敗血症性臓器不全 / 敗血症性多臓器不全 |
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| Outline of Final Research Achievements |
We measured HIF-1α protein levels and ATP concentrations in the lung tissues from septic mice. At the early stage, HIF-1α protein and ATP levels were increased. On the other hand, HIF-1α protein levels returned to the control level and ATP concentrations were decreased in the lung tissues at the late stage.
These observations suggest that modulation of HIF-1 might have therapeitic effects against septic mulitiple organ dysfunction syndrome through the improvement of energy metabolism.
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