| Project/Area Number |
26462764
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
Beppu Takaaki 岩手医科大学, 医学部, 教授 (70275543)
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| Co-Investigator(Kenkyū-buntansha) |
藤原 俊朗 岩手医科大学, 医学部, 助教 (60405842)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 一酸化炭素中毒 / 酸化ストレス / free-radicals / 大脳白質障害 / 慢性神経症状 / フリーラジカル / 慢性期神経障害 / MRI / ヒドロキシペルオキシド / 三価鉄還元 / diffusion kartosis / 拡散カルトーシス / 抗酸化能 |
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| Outline of Final Research Achievements |
We hypothesized that measurements of the extent of oxidative stress and anti-oxidative potential should be able to predict cerebral white matter damages after carbon monoxide (CO) poisoning. As a result, patients who showed more increase of oxidative stress as well as more decrease of anti-oxidative stress suffered severer brain damages afterward. As the another research, we compared chronic symptoms between patients treated with and without free-radical scavenger immediately after CO poisoning. Consequently, patients who were treated with free-radical scavenger tended to show milder symptoms than the other patient group.
These results suggested that internal free-radicals after CO poisoning plays a role of the mediators during the process from CO exposure and brain damage.
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