Establishment of predictive methods for clinical prognoses at ultra-acute and acute phases after carbon monoxide poisoning

• Project/Area Number: 26462764
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Iwate Medical University
• Principal Investigator: Beppu Takaaki 岩手医科大学, 医学部, 教授 (70275543)
• Co-Investigator(Kenkyū-buntansha): 藤原 俊朗 岩手医科大学, 医学部, 助教 (60405842)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 一酸化炭素中毒 / 酸化ストレス / free-radicals / 大脳白質障害 / 慢性神経症状 / フリーラジカル / 慢性期神経障害 / MRI / ヒドロキシペルオキシド / 三価鉄還元 / diffusion kartosis / 拡散カルトーシス / 抗酸化能

Outline of Final Research Achievements

We hypothesized that measurements of the extent of oxidative stress and anti-oxidative potential should be able to predict cerebral white matter damages after carbon monoxide (CO) poisoning. As a result, patients who showed more increase of oxidative stress as well as more decrease of anti-oxidative stress suffered severer brain damages afterward. As the another research, we compared chronic symptoms between patients treated with and without free-radical scavenger immediately after CO poisoning. Consequently, patients who were treated with free-radical scavenger tended to show milder symptoms than the other patient group.
These results suggested that internal free-radicals after CO poisoning plays a role of the mediators during the process from CO exposure and brain damage.

Research Products

• [Journal Article] MRI and 11C-methyl-L-methionine PET Differentiate Bevacizumab True Responders After Initiating Therapy for Recurrent Glioblastoma (2016)
  • Author(s): Beppu T, Terasaki K, Sasaki T, Sato Y, Tomabechi M, Kato K, Sasaki M, Ogasawara K.
  • Journal Title: Clin Nucl Med Volume: 41 Pages: 852-857
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Brain temperature measured by 1H-magnetic resonance spectroscopy in acute and subacute carbon monoxide poisoning patients. (2016)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogawa A, Ogasawara K, Beppu T
  • Journal Title: Neuroradiology Volume: 58 Pages: 27-32
  • DOI: 10.1007/s00234-015-1600-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of free radical scavenger, edaravone, for patients with carbon monoxide poisoning. (2015)
  • Author(s): Mori K, Beppu T, Fujisawa Y, Onodera M, Ogasawara K, Sasaki M, Ehara S, Sakai A, Endo S.
  • Journal Title: Clin Neurol Neurosurg Volume: 139 Pages: 59-61
  • DOI: 10.1016/j.clineuro.2015.09.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-uptake areas on positron emission tomography with the hypoxic radiotracer 18F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia. (2015)
  • Author(s): Beppu T, Sasaki T, Terasaki K, Saura H, Mtsuura H, Ogasawara K, Sasaki M, Ehara S, Iwata R, Takai Y
  • Journal Title: Ann. Nucl. Med. Volume: 29 Pages: 336-341
  • DOI: 10.1007/s12149-015-0951-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypoxic viable tissue in human chronic cerebral schemia because of unilateral major cerebral artery steno-occlusive disease. (2015)
  • Author(s): Saura H, Ogasawara K, Beppu T, Yoshida K, Kobayashi M, Yoshida K, Terasaki K, Takai Y, Ogawa A.
  • Journal Title: Stroke Volume: 46 Pages: 1250-1256
  • DOI: 10.1161/strokeaha.114.008238
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The role of MR imaging in assessing brain damage from carbon monoxide poisoning: a review of the literature. (2014)
  • Author(s): Beppu T
  • Journal Title: AJNR Am J Neuroradiol Volume: 35 Pages: 625-631
  • DOI: 10.3174/ajnr.a3489
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Standardized Uptake Value in High Uptake Area on Positron Emission Tomography with 18F-FRP170 as a Hypoxic Cell Tracer Correlates with Intratumoral Oxygen Pressure in Glioblastoma. (2014)
  • Author(s): Beppu T, Terasaki K, Sasaki T, Fujiwara S, Matsuura H, Ogasawara K, Sera K, Yamada N, Uesugi N, Sugai T, Kudo K, Sasaki M, Ehara S, Iwata R, Takai Y
  • Journal Title: Mol Imag Biol Volume: 16 Pages: 127-135
  • DOI: 10.1007/s11307-013-0670-7
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 再発膠芽腫に対するbevacizumab治療におけるMRIの見かけ効果の検討 (2015)
  • Author(s): 別府高明
  • Organizer: 第３３回日本脳腫瘍学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-12-06
• [Presentation] 岩手医科大学のHBO運営と卒前教育 (2015)
  • Author(s): 別府高明
  • Organizer: 第50回日本高気圧環境・潜水医学会学術総会
  • Place of Presentation: 群馬
  • Year and Date: 2015-11-13
  • Invited
• [Presentation] 75Frequency of pseudo-response on MRI at the early during bevacizumab treatment for recurrent glioblastoma. (2015)
  • Author(s): Beppu T
  • Organizer: The 38th ESNR Annual Meeting
  • Place of Presentation: Naples, Italy
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] 再発膠芽腫に対するbevacizumab/weekly temozolomide(BEV/wTMZ)における治療早期の画像効果判定 (2014)
  • Author(s): 別府高明
  • Organizer: 第32回日本脳腫瘍学会
  • Place of Presentation: 千葉
  • Year and Date: 2014-11-30 – 2014-12-02
• [Presentation] 減圧症の鑑別疾患 (2014)
  • Author(s): 別府高明
  • Organizer: 第49回日本高気圧環境・潜水医学会学術総会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-11-07 – 2014-11-08
  • Invited
• [Presentation] 再発膠芽腫に対するbevacizumab/weekly temozolomide(BEV/wTMZ)における治療早期の画像効果判定 (2014)
  • Author(s): 別府高明
  • Organizer: 第７３回日本脳神経外科総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11