Establishment of predictive methods for clinical prognoses at ultra-acute and acute phases after carbon monoxide poisoning
Project/Area Number |
26462764
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Emergency medicine
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Research Institution | Iwate Medical University |
Principal Investigator |
Beppu Takaaki 岩手医科大学, 医学部, 教授 (70275543)
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Co-Investigator(Kenkyū-buntansha) |
藤原 俊朗 岩手医科大学, 医学部, 助教 (60405842)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | 一酸化炭素中毒 / 酸化ストレス / free-radicals / 大脳白質障害 / 慢性神経症状 / フリーラジカル / 慢性期神経障害 / MRI / ヒドロキシペルオキシド / 三価鉄還元 / diffusion kartosis / 拡散カルトーシス / 抗酸化能 |
Outline of Final Research Achievements |
We hypothesized that measurements of the extent of oxidative stress and anti-oxidative potential should be able to predict cerebral white matter damages after carbon monoxide (CO) poisoning. As a result, patients who showed more increase of oxidative stress as well as more decrease of anti-oxidative stress suffered severer brain damages afterward. As the another research, we compared chronic symptoms between patients treated with and without free-radical scavenger immediately after CO poisoning. Consequently, patients who were treated with free-radical scavenger tended to show milder symptoms than the other patient group. These results suggested that internal free-radicals after CO poisoning plays a role of the mediators during the process from CO exposure and brain damage.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Effect of free radical scavenger, edaravone, for patients with carbon monoxide poisoning.2015
Author(s)
Mori K, Beppu T, Fujisawa Y, Onodera M, Ogasawara K, Sasaki M, Ehara S, Sakai A, Endo S.
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Journal Title
Clin Neurol Neurosurg
Volume: 139
Pages: 59-61
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma.2014
Author(s)
Beppu T, Terasaki K, Sasaki T, Fujiwara S, Matsuura H, Ogasawara K, Sera K, Yamada N, Uesugi N, Sugai T, Kudo K, Sasaki M, Ehara S, Iwata R, Takai Y
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Journal Title
Mol Imag Biol
Volume: 16
Pages: 127-135
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 減圧症の鑑別疾患2014
Author(s)
別府高明
Organizer
第49回日本高気圧環境・潜水医学会学術総会
Place of Presentation
鹿児島
Year and Date
2014-11-07 – 2014-11-08
Related Report
Invited
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