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Establishment of predictive methods for clinical prognoses at ultra-acute and acute phases after carbon monoxide poisoning

Research Project

Project/Area Number 26462764
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionIwate Medical University

Principal Investigator

Beppu Takaaki  岩手医科大学, 医学部, 教授 (70275543)

Co-Investigator(Kenkyū-buntansha) 藤原 俊朗  岩手医科大学, 医学部, 助教 (60405842)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords一酸化炭素中毒 / 酸化ストレス / free-radicals / 大脳白質障害 / 慢性神経症状 / フリーラジカル / 慢性期神経障害 / MRI / ヒドロキシペルオキシド / 三価鉄還元 / diffusion kartosis / 拡散カルトーシス / 抗酸化能
Outline of Final Research Achievements

We hypothesized that measurements of the extent of oxidative stress and anti-oxidative potential should be able to predict cerebral white matter damages after carbon monoxide (CO) poisoning. As a result, patients who showed more increase of oxidative stress as well as more decrease of anti-oxidative stress suffered severer brain damages afterward. As the another research, we compared chronic symptoms between patients treated with and without free-radical scavenger immediately after CO poisoning. Consequently, patients who were treated with free-radical scavenger tended to show milder symptoms than the other patient group.
These results suggested that internal free-radicals after CO poisoning plays a role of the mediators during the process from CO exposure and brain damage.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 6 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] MRI and 11C-methyl-L-methionine PET Differentiate Bevacizumab True Responders After Initiating Therapy for Recurrent Glioblastoma2016

    • Author(s)
      Beppu T, Terasaki K, Sasaki T, Sato Y, Tomabechi M, Kato K, Sasaki M, Ogasawara K.
    • Journal Title

      Clin Nucl Med

      Volume: 41 Pages: 852-857

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Brain temperature measured by (1)H-magnetic resonance spectroscopy in acute and subacute carbon monoxide poisoning2016

    • Author(s)
      Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogawa A, Ogasawara K, Beppu T
    • Journal Title

      Neuroradiology

      Volume: 58 Issue: 1 Pages: 27-32

    • DOI

      10.1007/s00234-015-1600-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of free radical scavenger, edaravone, for patients with carbon monoxide poisoning.2015

    • Author(s)
      Mori K, Beppu T, Fujisawa Y, Onodera M, Ogasawara K, Sasaki M, Ehara S, Sakai A, Endo S.
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 139 Pages: 59-61

    • DOI

      10.1016/j.clineuro.2015.09.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High-uptake areas on positron emission tomography with the hypoxic radiotracer 18F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia.2015

    • Author(s)
      Beppu T, Sasaki T, Terasaki K, Saura H, Mtsuura H, Ogasawara K, Sasaki M, Ehara S, Iwata R, Takai Y
    • Journal Title

      Ann Nucl Med

      Volume: 29 Issue: 4 Pages: 336-341

    • DOI

      10.1007/s12149-015-0951-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery steno-occlusive disease.2015

    • Author(s)
      Saura H, Ogasawara K, Beppu T, Yoshida K, Kobayashi M, Yoshida K, Terasaki K, Takai Y, Ogawa A.
    • Journal Title

      Stroke

      Volume: 46 Issue: 5 Pages: 1250-1256

    • DOI

      10.1161/strokeaha.114.008238

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The role of MR imaging in assessing brain damage from carbon monoxide poisoning: a review of the literature.2014

    • Author(s)
      Beppu T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 35 Issue: 4 Pages: 625-631

    • DOI

      10.3174/ajnr.a3489

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma2014

    • Author(s)
      Beppu T, Terasaki K, Sasaki T, Fujiwara S, Matsuura H, Ogasawara K, Sera K, Yamada N, Uesugi N, Sugai T, Kudo K, Sasaki M, Ehara S, Iwata R, Takai Y
    • Journal Title

      Mol Imaging Biol

      Volume: 16 Issue: 1 Pages: 127-135

    • DOI

      10.1007/s11307-013-0670-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 再発膠芽腫に対するbevacizumab治療におけるMRIの見かけ効果の検討2015

    • Author(s)
      別府高明
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 岩手医科大学のHBO運営と卒前教育2015

    • Author(s)
      別府高明
    • Organizer
      第50回日本高気圧環境・潜水医学会学術総会
    • Place of Presentation
      群馬
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 75Frequency of pseudo-response on MRI at the early during bevacizumab treatment for recurrent glioblastoma.2015

    • Author(s)
      Beppu T
    • Organizer
      The 38th ESNR Annual Meeting
    • Place of Presentation
      Naples, Italy
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 再発膠芽腫に対するbevacizumab/weekly temozolomide(BEV/wTMZ)における治療早期の画像効果判定2014

    • Author(s)
      別府高明
    • Organizer
      第32回日本脳腫瘍学会
    • Place of Presentation
      千葉
    • Year and Date
      2014-11-30 – 2014-12-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 減圧症の鑑別疾患2014

    • Author(s)
      別府高明
    • Organizer
      第49回日本高気圧環境・潜水医学会学術総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 再発膠芽腫に対するbevacizumab/weekly temozolomide(BEV/wTMZ)における治療早期の画像効果判定2014

    • Author(s)
      別府高明
    • Organizer
      第73回日本脳神経外科総会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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