• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on the relationships between water transportation through alveolar type II epithelial cells (dome formation) and development of pulmonary edema

Research Project

Project/Area Number 26462765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionIwate Medical University

Principal Investigator

Suwabe Akira  岩手医科大学, 医学部, 教授 (20241713)

Co-Investigator(Renkei-kenkyūsha) OGASAWARA RIE  岩手医科大学, 医学部, 助教 (70347871)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺水腫 / 肺胞II型上皮細胞 / ドーム形成 / 肺胞 II 型上皮細胞 / 肺胞 II 型細胞
Outline of Final Research Achievements

Disturbance in water transportation through alveolar type II epithelial cells was suggested to be involved in the development of pulmonary edema. In the present study, we established the in vitro system to evaluate the agents affecting the dome formation which reflects the water transportation through alveolar type II epithelial cells, using our original cell dynamic recording system with a special four-divided chamber. Using our system, it was suggested the agents such as drugs or biological active materials affecting the development of pulmonary edema can be evaluated.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (2 results) Presentation (3 results)

  • [Journal Article] 呼吸器疾患に関する細胞生物学 「肺胞上皮細胞」2016

    • Author(s)
      諏訪部 章
    • Journal Title

      Perpiratory Medical Research

      Volume: 4(2) Pages: 54-58

    • Related Report
      2015 Research-status Report
  • [Journal Article] 培養装置付き蛍光・位相差顕微鏡によるラット分離肺胞II型細胞の観察 ~接着・サーファクタント分泌・ドーム形成までの経時変化~2015

    • Author(s)
      諏訪部章、小笠原理恵
    • Journal Title

      分子呼吸器病

      Volume: 19(1) Pages: 115-117

    • Related Report
      2014 Research-status Report
  • [Presentation] 培養装置付き蛍光・位相差顕微鏡によるラット肺胞II型細胞の動的観察2016

    • Author(s)
      諏訪部章、小笠原理恵
    • Organizer
      第52回日本肺サーファクタント・界面医学会学術研究会
    • Place of Presentation
      金沢医科大学(金沢)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] A型インフルエンザウイルスによる肺炎の発症機構の解析:コラーゲン収縮ゲル上で培養したラット肺胞Ⅱ型細胞による検討2016

    • Author(s)
      佐々木裕、小笠原理恵、吉野直人、長内和弘、諏訪部章、村木靖
    • Organizer
      第52回日本肺サーファクタント・界面医学会学術研究会
    • Place of Presentation
      金沢医科大学(金沢)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺胞II型上皮細胞の形態(静的および動的)と機能2014

    • Author(s)
      諏訪部章
    • Organizer
      第50回日本肺サーファクタント・界面医学会学術研究会
    • Place of Presentation
      盛岡
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi