Evaluation of the mechanisms how beta blockade therapy for sepsis can protect sepsis-induced organ injuries
| Project/Area Number |
26462768
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
Takeshi Suzuki 慶應義塾大学, 医学部(信濃町), 講師 (80327600)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 敗血症 / β遮断薬 / Tリンパ球 / アポトーシス / 免疫能 / リンパ球 / 生存率 / 細胞死 / 臓器障害 |
|---|
| Outline of Final Research Achievements |
In this study, I evaluated the effect of beta blockade therapy on spleen T-lymphocytes in sepsis. After confirmation that catecholamine stimulation induced spleen T-lymphocytes apoptosis in a dose dependant manner, I evaluated the effect of beta blockade therapy on normal spleen T-lymphocytes, which were reduced according to the severity of sepsis. I used a cecum ligation and puncture (CLP) model as a septic model, which was a golden standard model for sepsis. Beta blockade therapy maintained the number of normal spleen T-lymphocytes, which were reduced dramatically in septic model. This result suggests that the preservation of immune function through manintenance of T-lymphocytes may be one of beneficial effects of beta blockde therapy in sepsis.
|
Report
(4 results)
Research Products
(2 results)
