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brain damage after heat stroke in mice

Research Project

Project/Area Number 26462769
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionShowa University (2016-2017)
Jikei University School of Medicine (2014-2015)

Principal Investigator

Dohi Kenji  昭和大学, 医学部, 教授 (20301509)

Co-Investigator(Kenkyū-buntansha) 大滝 博和  昭和大学, 医学部, 准教授 (20349062)
小川 武希  東京慈恵会医科大学, 医学部, 教授 (90119769)
宮本 和幸  昭和大学, 医学部, 助教 (80555087)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords熱中症 / 水素水 / モデル / マウス / 動物モデル / 酸化ストレス / 神経損傷 / フリーラジカル / 治療法
Outline of Final Research Achievements

The purpose of this project was to clarify the pathophysiology of neuroinflammation in mice heat stroke model. We developed mice heat stroke model which was not established. We also clarified the beneficial effect of the mineral supplement in heat stroke. The evaluation of the oxidative stress in heat stroke and the development of the new treatment using the hydrogen water is undergoing. We also found that heat stress cause intestinal tract damage. Basis of these results, we will clarify the relations with neuroinflammation and systemic inflammation in heat stroke.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Oral rehydration solution increases SGLT1 and improves dehydration in a mouse heatstroke model.2018

    • Author(s)
      Miyamoto K, Ohtaki H, Takayasu H, Maeda A, Sasaki J, Honda K, Dohi K, Hayashi M.
    • Journal Title

      Critical Care Medicine

      Volume: 46 Issue: 1 Pages: 252-252

    • DOI

      10.1097/01.ccm.0000528551.63676.f8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Neuroprotection and Neuroresuscitation in Neuroemergency Diseases2018

    • Author(s)
      Dohi Kenji
    • Journal Title

      Showa Univ J Med Sci

      Volume: 29

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration2017

    • Author(s)
      kenji Dohi, Kazue Satoh, Kazuyuki Miyamoto, Shunsuke Mommma, Kenichiro Fukuda, Ryo Higuchi, Hirokazu Ohtaki, Williams A Banks
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 61 Issue: 1 Pages: 1-5

    • DOI

      10.3164/jcbn.16-87

    • NAID

      130006847653

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice.2017

    • Author(s)
      Murai N, Ohtaki H, Watanabe J, Xu Z, Sasaki S, Yagura K, Shioda S, Nagasaka S, Honda K, Izumizaki M.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 10 Pages: e0186637-e0186637

    • DOI

      10.1371/journal.pone.0186637

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion.2017

    • Author(s)
      Sasaki S, Watanabe J, Ohtaki H, Matsumoto M, Murai N, Nakamachi T, Hannibal J, Fahrenkrug J, Hashimoto H, Watanabe H, Sueki H, Honda K, Miyazaki A, Shioda S.
    • Journal Title

      Br J Dermatol.

      Volume: 176 Issue: 2 Pages: 413-422

    • DOI

      10.1111/bjd.14885

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Oral rehydration solution improves thermoregulation in a mouse heatstroke model2017

    • Author(s)
      Kazuyuki Miyamoto, Hirokazu Ohtaki, Hiromi Takayasu, Atsuro Maeda, Jun Sasaki, Kazuho Honda, Munetaka Hayashi, Kenji Dohi
    • Journal Title

      Critical Care Medicine

      Volume: 44 Pages: 402-402

    • Related Report
      2016 Research-status Report
  • [Presentation] マウス熱中症モデルにおける経口補水液(OS-1)の有用性について2018

    • Author(s)
      宮本和幸, 大滝博和, 髙安弘美, 前田敦雄, 佐々木純, 本田一穂, 土肥謙二, 林宗貴
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳蘇生神経保護療法の開発を目指して ~基礎から臨床的検討、そして未来へ2018

    • Author(s)
      土肥謙二
    • Organizer
      第64回昭和大学 学士会 総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] マウス熱中症モデルにおける経口補水液の効果について2017

    • Author(s)
      宮本和幸、大滝博和、高安弘美、前田敦雄、佐々木純、本多一穂、土肥謙二、林宗貴
    • Organizer
      第44回日本集中治療医学会総会・学術集会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2017-03-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Oral rehydration solution improves thermoregulation in a mouse heatstroke model2017

    • Author(s)
      Kazuyuki Miyamoto, Hirokazu Ohtaki, Hiromi Takayasu, Atsuro Maeda, Jun Sasaki, Kazuho Honda, Munetaka Hayashi, Kenji Dohi
    • Organizer
      46th Critical Care Medicine
    • Place of Presentation
      Hawaii, Honolulu, USA
    • Year and Date
      2017-01-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Production of MCP-1 (CCL2) from human mesenchymal stem/stromal cells in ischemic brain2017

    • Author(s)
      2.Hirokazu Ohtaki, Kazumichi Yagura, Yuki Tanaka, Jun Watanabe, Kazuyuki Miyamoto, Yutaka Hiraizumi, Kenji Dohi, Kazuho Honda
    • Organizer
      第40回日本神経科学大会(幕張メッセ,千葉)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Suppression of nitric oxide level from microglia by co-culturing with human mesenchymal stem/progenitor cells2017

    • Author(s)
      8.Ohtaki H, Watanabe J, Yagura K, Miyamoto K, Hiraizumi Y, Honda K, Dohi K
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic time-window for edaravone treatment of traumatic brain injury in mice.2017

    • Author(s)
      Miyamoto Kazuyuki, Ohtaki Hirokazu, Dohi, Kenji, Sitho Hiromi, Maeda Atsuo, Sasaki Jun, Honda Kazuho, Hayashi Munetaka
    • Organizer
      8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human recombinant thrombomodulin (rTM) improves the neurological function in a murine heatstroke model2016

    • Author(s)
      Kazuyuki Miyamoto
    • Organizer
      45th Society of Critical Care Medicine
    • Place of Presentation
      Orland, USA
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Neurocritical care2019

    • Author(s)
      Dohi kenji
    • Publisher
      springer
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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