| Project/Area Number |
26462771
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nagoya City University (2015-2017)
Fujita Health University (2014) |
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Principal Investigator |
Hattori Tomonori 名古屋市立大学, 大学院医学研究科, 教授 (90363936)
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| Co-Investigator(Kenkyū-buntansha) |
武山 直志 愛知医科大学, 医学部, 准教授 (00155053)
秦 龍二 藤田保健衛生大学, 医学部, 教授 (90258153)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 敗血症 / 免疫不全 / 骨髄移植 / T細胞 / 骨髄幹細胞 / immunoparalysis / 骨髄幹細胞移植 |
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| Outline of Final Research Achievements |
In septic shock patients, serial blood samples were obtained on days 1, 3, and 7 after the onset of shock, and immune cell subsets and receptor expression were characterized. A decrease of immunoactivity of T cells and monocyte were observed in the early stage of septic shock. Significant lymphopenia persisted for at least 7 days following the onset of septic shock. Normalization of immunodysfunctions was observed by day 7, except in patients who died. Our findings emphasize the importance of normal lymphocyte function for recovery from septic shock. These results indicate that the regeneration of the immunoparalytic state by bone-marrow transplantation, can be potentially effective therapy for recovery from septic shock.
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