| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Stroke is the leading cause of disability and the third cause of death in the world. Despite intense investigations, no therapy that prevents stroke-induced brain damage and neurological dysfunction has emerged. Recently a growing number of evidence supports regenerative medicine is working to restore structure and function of damaged brain tissues. In this study, we investigated the effects of transplantation of the neural stem cell derived from ES cells on cerebral ischemia. Consequently we have demonstrated that neural stem cells derived from embryonic stem cells have shown protective effects on ischemic insults. Our results have suggested that stem cell therapy has proven effective in promoting functional recovery and protecting secondary degeneration of the thalamus in animal models of cerebral ischemia and therefore represents a hopeful therapy for this unmet medical condition, although further investigations must be required to clarify their repair mechanisms in the brain.
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