ES derived neuronal stem cells ameliorate ischemic brain injury in mice

• Project/Area Number: 26462772
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Fujita Health University
• Principal Investigator: Hata Ryuji 藤田保健衛生大学, 医学部, 教授 (90258153)
• Co-Investigator(Kenkyū-buntansha): 武山 直志 愛知医科大学, 医学部, 教授 (00155053)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳血管障害 / 神経再生 / ES細胞 / 脳虚血 / 神経幹細胞 / 再生医療

Outline of Final Research Achievements

Stroke is the leading cause of disability and the third cause of death in the world. Despite intense investigations, no therapy that prevents stroke-induced brain damage and neurological dysfunction has emerged. Recently a growing number of evidence supports regenerative medicine is working to restore structure and function of damaged brain tissues. In this study, we investigated the effects of transplantation of the neural stem cell derived from ES cells on cerebral ischemia. Consequently we have demonstrated that neural stem cells derived from embryonic stem cells have shown protective effects on ischemic insults. Our results have suggested that stem cell therapy has proven effective in promoting functional recovery and protecting secondary degeneration of the thalamus in animal models of cerebral ischemia and therefore represents a hopeful therapy for this unmet medical condition, although further investigations must be required to clarify their repair mechanisms in the brain.

Research Products

• [Journal Article] Patients that have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer's Disease by Removal of Blood Amyloid. (2016)
  • Author(s): Sakai K, Senda T, Hata R, Kuroda M, Hasegawa M, Kato M, Abe M, Kawaguchi K, Nakai S, Hiki Y, Yuzawa Y, Kitaguchi N
  • Journal Title: J Alzheimers Dis. Volume: 51 Issue: 4 Pages: 997-1002
  • DOI: 10.3233/jad-151139
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intravenous infusion of ginsenoside Rb1 ameliorates compressive spinal cord injury through upregulation of Bcl-xL and VEGF (2015)
  • Author(s): Zhu P, Hata R, Nakata K, Cao F, Samukawa K, Fujita H, Sakanaka M
  • Journal Title: International Journal of Neurology and Neurotherapy Volume: 2 Pages: 2-7
  • Peer Reviewed / Open Access
• [Journal Article] Intravenous administration of bone marrow mononuclear cells alleviates hearing loss after transient (2014)
  • Author(s): Takagi T, Yoshida T, Okada M, Hata R, Hato N, Gyo K, Hakuba N.
  • Journal Title: Neuroreport Volume: 25 Pages: 807-813
  • Peer Reviewed / Acknowledgement Compliant