| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We performed comprehensive analysis of Rab GTPase family proteins in autophagy against bacterial pathogens. We identified Rab35 as a novel autophagy regulator. Rab35 binds to NDP52 and regulates the recruitment of NDP52 to invading bacteria. We also found that NLRP4, intracellular pattern recognition receptor, is recruited to invaded bacteria and regulates Rho signaling via RhoGDI to promote the fusion between recycling endosomes and autophagosomes. The fusion step is required for the extension of autophagosome membranes and form complete autophagosomes. Taken together, we revealed how host cells recognize pathogens and induce selective autophagy.
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