Elucidation of construction mechanism of extracellular environment around tooth germs via proteoglycan
| Project/Area Number |
26462777
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
Ida Hiroko 新潟大学, 医歯学系, 准教授 (60293213)
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| Co-Investigator(Kenkyū-buntansha) |
柴田 俊一 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80187400)
武内 恒成 愛知医科大学, 医学部, 教授 (90206946)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSHIMA Hayato 新潟大学, 医歯学系, 教授 (70251824)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | プロテオグリカン / コンドロイチン硫酸 / 歯胚 / 細胞外環境 / 顎顔面発育 / 頭蓋顔面発育 / 細胞外基質 |
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| Outline of Final Research Achievements |
Chondroitin sulfate proteoglycan (CSPG) is one of major extracellular matrices and is known to play an important part in organogenesis. To elucidate the role of CS in tooth and craniofacial development and regeneration, we analyzed the craniofacial morphology in chondroitin sulfate synthetic enzyme knockout (CSKO) mice. In normal odontogenesis, the CS chain localized in immature dental papilla and periodontal ligament. In the differentiated dental pulp, CS chain restricted to the apex of tooth root. In CSKO mice, some of KO mice exhibited severe facial developmental defect. Although most of CSKO mice showed normal postnatal development, they exhibited the deformation of cranial bone and malocculusion. These results suggest that CS chain is necessary for normal tooth and craniofacial morphogenesis.
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Report
(4 results)
Research Products
(15 results)
