Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis
| Project/Area Number |
26462783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Fujii Masae 岡山大学, 歯学部, 博士研究員 (30362685)
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| Co-Investigator(Kenkyū-buntansha) |
武部 祐一郎 岡山大学, 歯学部, 博士研究員 (00714677)
長塚 仁 岡山大学, 医歯薬学総合研究科, 教授 (70237535)
辻極 秀次 岡山理科大学, 理学部, 教授 (70335628)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腫瘍微小環境 / 骨髄由来細胞 / 血球系細胞 / 腫瘍 / 腫瘍間質 / GFP骨髄移植マウス / 骨髄移植 / 骨幹細胞 |
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| Outline of Final Research Achievements |
The activated tumor stroma participates tumor cell growth, invasion and metastasis has been the subject of recent studies. In the present study, bone marrow-derived cells in tumor stroma were traced using the GFP bone marrow transplantation model. The result revealed that a population of GFP positive cells showed peripheralis tumor par parenchyma more than tumor center. Cancer-associated fibroblasts (CAFs) represent the major cellular component of the stroma. Bone marrow-derived cells might differentiate into inflammatory cells (tumor associated macrophage(TAMs) and endothelial cells that suggested promote tumor invasion.
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Report
(5 results)
Research Products
(11 results)
