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A new reconstruction method using intraosseous microenvironment reproduction system of segmental excision bone

Research Project

Project/Area Number 26462784
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionOkayama University of Science

Principal Investigator

TSUJIGIWA Hidetsugu  岡山理科大学, 理学部, 教授 (70335628)

Co-Investigator(Kenkyū-buntansha) 武部 祐一郎  岡山大学, 歯学部, その他 (00714677)
山近 英樹  岡山大学, 大学病院, 講師 (10294422)
長塚 仁  岡山大学, 医歯薬学総合研究科, 教授 (70237535)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨組織 / 再生 / TCP
Outline of Final Research Achievements

Various ceramics has been researched as biomaterials for bone reconstruction materials since long time ago. However, these biomaterials are difficult to reconstruct bone defect in view of survival rate, strength, and osteoinductive efficiency. Thus in this study, when honeycomb TCP having through holes of diameter 300 μm was applied to zygomatic bone defect, bone construction formation similar normal bone tissue was recognized, and the continuity of bone tissue was restored. Moreover, in prolonged observation, the honeycomb TCP was absorbed and deformed, and restored to almost the same form as the normal zygomatic bone. From the above, it is considered that this material is a very excellent biomaterial.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results)

  • [Journal Article] Efficacy of Honeycomb TCP-induced Microenvironment on Bone Tissue Regeneration in Craniofacial Area2016

    • Author(s)
      Watanabe S, Takabatake K, Tsujigiwa H, Watanabe T, Tokuyama E, Ito S, Nagatsuka H, Kimata Y.
    • Journal Title

      Int J Med Sci

      Volume: 13(6) Issue: 6 Pages: 466-476

    • DOI

      10.7150/ijms.15560

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Migration and Differentiation of GFP-transplanted Bone Marrow-derived Cells into Experimentally Induced Periodontal Polyp in Mice2016

    • Author(s)
      Matsuda S, Shoumura M, Osuga N, Tsujigiwa H, Nakano K, Okafuji N, Ochiai T, Hasegawa H, Kawakami T.
    • Journal Title

      Int J Med Sci

      Volume: 13(7) Issue: 7 Pages: 500-506

    • DOI

      10.7150/ijms.15671

    • NAID

      120006422718

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] H2SO4/HCL(混酸・加熱)処理を施した造形チタンメッシュの骨形成能に関するX線学的・組織科学的検討2016

    • Author(s)
      山本佳代子、伊藤雄一、小越菜保子、寺井陽彦、有吉靖則、山口誠二、 辻極秀次、長塚 仁、植野高章
    • Organizer
      第25回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] GFP骨髄移植マウスの異所性骨形成における骨髄由来細胞の関与について2016

    • Author(s)
      于 淞、高畠清文、辻極秀次、松田寛之、河合穂高、吉田沙織、中野敬介、 長塚 仁
    • Organizer
      第25回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 異所性骨形成微小環境における骨髄幹細胞の関与2016

    • Author(s)
      高畠 清文、松田 寛之、辻極 秀次、于 淞、藤井 昌江、中野 敬介、 長塚 仁
    • Organizer
      第70回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ハニカムβ-TCPを用いた骨・軟骨組織形成制御2015

    • Author(s)
      高畠清文、辻極秀次、于 淞、伊藤 聡、松田寛之、河合穂高、信長ひかり、中野敬介、長塚 仁
    • Organizer
      第36回岡山市歯学会総会・学術集会
    • Place of Presentation
      岡山県
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
  • [Presentation] GFP骨髄移植マウスを用いた、異所性骨形成過程における骨髄由来細胞の役割の検討2015

    • Author(s)
      松田寛之、辻極秀次、高畠清文、伊藤 聡、藤井昌江、野敬介、長塚 仁
    • Organizer
      第24回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] ハニカムβ-TCPを用いた幾何学構造による骨・軟骨組織再生制御2015

    • Author(s)
      高畠清文,辻極秀次,于 淞、武部祐一郎、伊藤 聡、藤井昌江、松田寛之、河合穂高、長塚 仁
    • Organizer
      第69回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-05-13
    • Related Report
      2015 Research-status Report
  • [Presentation] ハニカムβ-TCPを用いた細胞外微小環境再現による硬組織再生2014

    • Author(s)
      高畠清文、辻極秀次、武部祐一郎、藤井昌江、河合穂高、于 淞、長塚 仁
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Transplanted bone marrow-derived cell migration into periodontal tissue and cell differentiation.2014

    • Author(s)
      Tsujigiwa H, Murata R, Nakano K, Tomida M, Takabatake K, Tamamura R, Nagatsuka H.
    • Organizer
      The 7th Asian Science Seminar in TAIWAN
    • Place of Presentation
      Taiwan
    • Year and Date
      2014-08-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Pathological examination of periodontal polyp induced experimentally in mice.2014

    • Author(s)
      Matsuda S, Nakano K, Shoumura M, Osuga N, Tsujigiwa H, Kawakami T.
    • Organizer
      The 7th Asian Science Seminar in TAIWAN
    • Place of Presentation
      Taiwan
    • Year and Date
      2014-08-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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