| Project/Area Number |
26462792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Matsuo Kou 九州歯科大学, 歯学部, 教授 (70238971)
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| Co-Investigator(Kenkyū-buntansha) |
自見 英治郎 九州歯科大学, 歯学部, 教授 (40276598)
板井 昭子 株式会社医薬分子設計研究所, その他部局等, その他 (60012647)
藤川 智行 株式会社医薬分子設計研究所, その他部局等, 研究員(移行) (30451074)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔扁平上皮癌 / NF-κB / IκBキナーゼβ / IMD-056 / NF-kB / IkBキナーゼb / IMD-0560 / IkBキナーゼβ |
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| Outline of Final Research Achievements |
Gingival oral squamous cell carcinoma (OSCC)frequently invade the maxilla or the mandibular bone and are associated with poor prognosis. Thus, we investigated whether the novel NFkB inhibitors suppress bone invasion by OSCC. NF-kB inhibitors suppress proliferation and stimulate apoptosis of OSCC cells in vitro and in vivo. NF-kB inhibitors also inhibit matrix metalloproteinase (MMPs) production in OSCC. Furthermore, NF-kB inhibitors have been shown to suppress osteoclastogenesis by reducing RANKL expression in animal models. Thus, inhibition of NF-kB activity may constitute a promising therapeutic approach to treat bone-invasive OSCC
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