| Project/Area Number |
26462793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮川 博史 北海道医療大学, 歯学部, 講師 (30219729)
藤田 真理 北海道医療大学, 歯学部, 助教 (50405669)
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| Co-Investigator(Renkei-kenkyūsha) |
MASHIMA Izumi 日本学術振興会, 特別研究員 (60770782)
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| Research Collaborator |
CITRA F. Theodorea 北海道医療大学, 大学院歯学研究科, 大学院生
THAWEBOON Boonyanit Mahidol University, Department of Oral Microbiology, Faculty of Dentistry, 講師
THAWEBOON Sroisiri Mahidol University, Department of Oral Microbiology, Faculty of Dentistry, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔バイオフィルム / Veillonella / Streptococcus / メタゲノム解析 / 口腔清掃 / 唾液の細菌叢 / rpo B / 新菌種 / Oral biofilm / Oral Veillonella / V. tobetsuensis, / periodontitis / ﾄﾞﾗﾌﾄｹﾞﾉﾑｼｰｸｴﾝｽ / 口腔細菌学 / 口腔ﾊﾞｲｵﾌｨﾙﾑ / Oral Streptococcus / 歯周ﾎﾟｹｯﾄ / Initial Colonizer / Early Colonizer |
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| Outline of Final Research Achievements |
Ora biofilm cause dental caries and periodotal disease. Streptcoccus and Veillonella are known to have important roles in the biofilm formation at aerly stage.This study demonstrated the following results. 1. Auto inducer from V. tobetsuensis inhibited biofilm formation of S. gordonii. 2. Draft genome of V. tobetsuensis was revealed. 3. New method for identification of all veillonella species was established. 4. Based on metagenome analysis of saliva, it was demonstrated that Streptococcus species incresed in good oral hygiene, but Veillonella species incresde in poor ora hygiene. 5. Many unknown Veillonella species inhabited in oral cavities with poor oral hygiene.
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