| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The present study was designed to investigate whether swallowing reflex in rat is modulated by JZL184, an inhibitor of the main degradation enzyme of a major endocannabinoid named 2-arachydonoylglycerol (2-AG). Intrathecal (IT) application of JZL184 reduced the latency of onset of swallowing reflex evoked by electrical stimulation of the superior laryngeal nerve (SLN). Findings of immunohistochemical study indicated that JZL184 application (IT) reduced production of the degradation enzyme monoacylglycerol lipase (MAGL), thereby increased the accumulation of 2-AG in the swallowing center of the nucleus tractus solitaries. These findings suggest that increase accumulation of endocannabinoid by preventing its degradation in the swallowing center can facilitate the triggering of swallowing reflex.
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