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Neural mechanisms of salivary secretion related to oral senses and mastication.

Research Project

Project/Area Number 26462811
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionOkayama University

Principal Investigator

MATSUO Ryuji  岡山大学, 医歯薬学総合研究科, 教授 (30157268)

Co-Investigator(Kenkyū-buntansha) 美藤 純弘  岡山大学, 医歯薬学総合研究科, 助教 (20240872)
藤田 雅子  岡山大学, 医歯薬学総合研究科, 助手 (40156881)
寺山 隆司  岡山大学, 医歯薬学総合研究科, 准教授 (60333689)
小橋 基  岡山大学, 医歯薬学総合研究科, 准教授 (80161967)
Research Collaborator Carpenter Guy H.  Oral Biology, Salivary Research Unit, Kings College London Dental Institute, Lecturer
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords唾液分泌 / 咀嚼 / 口腔感覚 / 摂食中枢 / 大脳皮質 / 味覚 / 感覚神経 / 視床下部外側野 / 飲水 / 歯ぎしり / 毛づくろい
Outline of Final Research Achievements

The neural mechanism for salivary secretion induced by mastication and oral senses was investigated by electrophysiological techniques in the rat. As the result, we found that oral senses are cue sign for starting and determining patterns of both mastication and salivation. This suggests that salivation is not a result of mastication or oral sensory information. Secreted saliva dissolves foods and helps to make sense of taste, affecting taste quality and intensity. Moreover, saliva protects taste receptors in the oral cavity. Mastication, salivation, and oral senses are affected each other.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 3 results) Book (2 results) Remarks (3 results)

  • [Journal Article] 唾液分泌異常と自律神経2015

    • Author(s)
      松尾龍二、小橋 基
    • Journal Title

      JOHNS

      Volume: 31 Pages: 1017-1019

    • Related Report
      2015 Research-status Report
  • [Journal Article] GLP-1の嚥下反射減弱作用に及ぼすオレキシンAの効果2015

    • Author(s)
      小橋基、水谷諭史、藤田雅子、美藤純弘、島谷祐一、松尾龍二
    • Journal Title

      日本味と匂学会誌

      Volume: 22 Pages: 371-374

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of the lateral hypothalamus in submandibular salivary secretion during feeding in rats.2015

    • Author(s)
      Matsuo R, Kobashi M, Mitoh Y, Fujita M
    • Journal Title

      Brain Research

      Volume: 1596 Pages: 99-107

    • DOI

      10.1016/j.brainres.2014.11.026

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GLP-1中枢投与による反射性嚥下抑制を惹起する部位の同定2014

    • Author(s)
      水谷諭史、小橋基、島谷祐一、藤田雅子、美藤純弘、水谷雅年、松尾龍二
    • Journal Title

      日本味と匂学会誌

      Volume: 21 Pages: 245-248

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 多機能な消化器官としての口腔機能2017

    • Author(s)
      松尾龍二
    • Organizer
      第21回口腔顔面神経機能学会
    • Place of Presentation
      岡山大学病院(岡山市)
    • Year and Date
      2017-03-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 口腔機能と栄養摂取2016

    • Author(s)
      松尾龍二
    • Organizer
      NST会議
    • Place of Presentation
      岡山大学病院(岡山市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] GLP-1 の嚥下反射減弱作用に及ぼすオレキシン A の効果2015

    • Author(s)
      小橋基、水谷諭史、藤田雅子、美藤純弘、島谷祐一、松尾龍二
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 味覚障害と唾液分泌の重要性 -基礎研究からの提言-2014

    • Author(s)
      松尾 龍二
    • Organizer
      第59回日本唾液腺学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] GLP-1 中枢投与による反射性嚥下抑制を惹起する部位の同定2014

    • Author(s)
      水谷 諭史、小橋 基、島谷 祐一、藤田 雅子、美藤 純弘、水谷 雅年
    • Organizer
      日本味と匂学会第48回大会
    • Place of Presentation
      静岡市
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 渋味溶液の舌刺激による舌神経と鼓索神経の応答と温度覚との関連2014

    • Author(s)
      美甘 真、兒玉 直紀、美藤 純弘、小橋 基、皆木 省吾、松尾 龍二
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] オレキシンはラット顎下唾液腺を支配する上唾液核ニューロンを興奮させる2014

    • Author(s)
      美藤純弘、佐藤 匡、藤田雅子、小橋基、市川博之、松尾龍二
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Book] 唾液・唾液腺2016

    • Author(s)
      松尾龍二、村上政隆、谷村明彦(他17名、8番目)
    • Total Pages
      208
    • Publisher
      金原出版
    • Related Report
      2016 Annual Research Report
  • [Book] The role of saliva in taste transduction. In: Handbook of Olfaction and Gustation2015

    • Author(s)
      Matsuo, R. and Carpenter, Guy H.
    • Total Pages
      1217
    • Publisher
      Wiley Blackwell, Hoboken, New Jersey
    • Related Report
      2015 Research-status Report
  • [Remarks] 医歯学系総合研究業績目録

    • Related Report
      2016 Annual Research Report
  • [Remarks] 医歯学系総合研究業績目録

    • Related Report
      2015 Research-status Report
  • [Remarks] 医歯学系総合研究業績目録

    • URL

      http://www.okayama-u.ac.jp/user/med/Gyoseki/Gyoseki_md/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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