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Elucidation of Molecular Mechanism of the Salivary Gland Regeneration ~ Toward the application to the Regenerative Medicine for Xerostomia ~

Research Project

Project/Area Number 26462814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

Akamatsu Tetsuya  徳島大学, 大学院生物資源産業学研究部, 准教授 (80294700)

Co-Investigator(Kenkyū-buntansha) 姚 陳娟  徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (20432750)
吉村 弘  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (90288845)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords顎下腺 / 再生 / サチライシン様前駆体蛋白質変換酵素 / PACE4 / 水チャネル / AQP5 / 雌雄差
Outline of Final Research Achievements

Ligation and re-opening of the main excrete duct of submandibular gland is used as regeneration model of salivary gland.
No change was observed in the contralateral glands of ligated rats, while the atrophy and weight decrease of ligated gland was observed. These changes were also observed in the re-opening group, but the recovery of gland weight was significantly observed in female rats than male rats. By Western blotting, the induction and changes of expressions of PACE4 and AQP5 were observed in the ligated glands, but not in the contralateral glands. In male rats, inverse correlation of the expression levels of PACE4 and AQP5 was observed, but not in female rats. Although it is still preliminary, we found the induction and changes of expressions of PACE4 and AQP5 in the ligated glands of ovariectomized rats seemed to be like male rats, suggesting the involvement of sex hormone in sexual difference of the salivary gland regeneration.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] 唾液腺の構造と機能2016

    • Author(s)
      赤松徹也
    • Journal Title

      J Oral Health & Biosci

      Volume: 28 Pages: 77-86

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Sexual difference in the regeneration model of the rat submandibular gland2016

    • Author(s)
      Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa, Hiroshi Yoshimura
    • Organizer
      The 4th International Symposium on Salivary Glands in Honor of Niels Stensen
    • Place of Presentation
      自然科学研究機構岡崎カンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induced expression of a subtilisin-like proprotein convertase PACE4 in the regeneration model of rat submandibular gland2016

    • Author(s)
      Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa, Hiroshi Yoshimura
    • Organizer
      The 4th International Symposium on Salivary Glands in Honor of Niels Stensen
    • Place of Presentation
      自然科学研究機構岡崎カンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 唾液腺再生過程で見られる雌雄差について2016

    • Author(s)
      赤松徹也,姚陳娟,長谷川敬展,吉村弘
    • Organizer
      第58回歯科基礎医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 唾液腺再生モデルにおけるサチライシン様前駆体蛋白質変換酵素PACE4の発現誘導-Part II-2016

    • Author(s)
      嶋谷達哉,嶺岸誠,赤松徹也,姚陳娟,長谷川敬展,吉村弘
    • Organizer
      第58回歯科基礎医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 唾液腺の構造と機能2015

    • Author(s)
      赤松徹也
    • Organizer
      第47回四国歯学会例会
    • Place of Presentation
      徳島大学歯学部(徳島県徳島市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC42014

    • Author(s)
      Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa, and Hiroshi Yoshimura
    • Organizer
      BIT's 1st Annual World Congress of Oral & Dental Medicine
    • Place of Presentation
      Haikou (China)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 唾液腺再生モデルにおける水チャネルAQP5の発現2014

    • Author(s)
      姚陳娟,赤松徹也,長谷川敬展,吉村弘
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 唾液腺再生モデルにおけるサチライシン様前駆体蛋白質変換酵素の発現誘導2014

    • Author(s)
      嶺岸誠,赤松徹也,姚陳娟,長谷川敬展,吉村弘
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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