Elucidation of Molecular Mechanism of the Salivary Gland Regeneration ~ Toward the application to the Regenerative Medicine for Xerostomia ~
| Project/Area Number |
26462814
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
Akamatsu Tetsuya 徳島大学, 大学院生物資源産業学研究部, 准教授 (80294700)
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| Co-Investigator(Kenkyū-buntansha) |
姚 陳娟 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (20432750)
吉村 弘 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (90288845)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 顎下腺 / 再生 / サチライシン様前駆体蛋白質変換酵素 / PACE4 / 水チャネル / AQP5 / 雌雄差 |
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| Outline of Final Research Achievements |
Ligation and re-opening of the main excrete duct of submandibular gland is used as regeneration model of salivary gland.
No change was observed in the contralateral glands of ligated rats, while the atrophy and weight decrease of ligated gland was observed. These changes were also observed in the re-opening group, but the recovery of gland weight was significantly observed in female rats than male rats. By Western blotting, the induction and changes of expressions of PACE4 and AQP5 were observed in the ligated glands, but not in the contralateral glands. In male rats, inverse correlation of the expression levels of PACE4 and AQP5 was observed, but not in female rats. Although it is still preliminary, we found the induction and changes of expressions of PACE4 and AQP5 in the ligated glands of ovariectomized rats seemed to be like male rats, suggesting the involvement of sex hormone in sexual difference of the salivary gland regeneration.
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Report
(4 results)
Research Products
(9 results)
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[Presentation] 唾液腺の構造と機能2015
Author(s)
赤松徹也
Organizer
第47回四国歯学会例会
Place of Presentation
徳島大学歯学部（徳島県徳島市）
Year and Date
2015-06-25
Related Report
Invited
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