Investigation of sensory integration in the insular cortex -multiple in vivo patch clamp analysis-
| Project/Area Number |
26462824
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Meikai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
小林 真之 日本大学, 歯学部, 教授 (00300830)
|
|---|
| Research Collaborator |
AOKI Ryuhei
NAGAO Takahide
ODAI Reina
SAITO Yoshihiro
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 島皮質 / 侵害受容 / 錐体細胞 / patch clamp / ラット / in vivo / whole-cell patch clamp |
|---|
| Outline of Final Research Achievements |
The spontaneous membrane potential oscillation of cortical pyramidal neuron is characterized by up state, a short depolarization period, and down state that included following after hyperpolarization (AHP) and resting membrane potential. Up state of agranular insular (AI) cortical pyramidal neurons was less exhibited compared with those of somatosensory cortical neurons. GABAA agonist increased and prolonged AHP. Electrical tongue stimulation induced EPSPs in AI neurons located 1 mm rostral from middle central artery with high incidence. In more rostral region, same stimulation induced IPSPs with low incidence.
|
Report
(4 results)
Research Products
(6 results)
