| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Establishment of physiological time measurement using saliva is required for the advanced dental care based on biological rhythms. Then, we have found ARRB1 as a candidate of the marker for physiological time measurement in saliva from the results of the gene expression profile. ARRB1 protein showed the circadian profile even using various saliva samples, suggesting a usefulness of this marker protein. We also found that the buffer containing 4 M Urea is adequate for saliva storage to prevent proteolysis and that the rhythm in saliva should be corrected using Actin as an internal control.
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