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Therapeutic innovation in oral mucosal leasions with erosion and ulcer by analyzing antigen presenting ability and autophagy

Research Project

Project/Area Number 26462832
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku University

Principal Investigator

Sugawara Yumiko  東北大学, 大学病院, 助教 (30235866)

Co-Investigator(Kenkyū-buntansha) 笹野 高嗣  東北大学, 歯学研究科, 教授 (10125560)
菅原 俊二  東北大学, 歯学研究科, 教授 (10241639)
西岡 貴志  東北大学, 歯学研究科, 助教 (50641875)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔粘膜 / びらん・潰瘍病変 / 口腔扁平苔癬 / 抗原提示能 / オートファジー / 治療法 / 口腔粘膜疾患 / 剥離細胞診 / 組織細胞診 / 組織診断 / 細胞診断
Outline of Final Research Achievements

Retrospective study was performed at 12 facilities on efficacy and safety of Cepharanthin (CEP) long-term use for the patient with oral lichen planus (OLP). The degree of the severity classified to, before and after 4weeks and 6 months and at the end point of the CEP use was assessed. The mean dosage period of the CEP use was 415 days, and the daily average dosage was 11.6mg. The high improvement rate was accepted in almost all clinical types and the location of the lesions by CEP use. Long-term use showed the higher efficacy for improving OLP. On the other hand, the dosage of CEP showed no significant difference for the improvement of OLP. High improvement rate was recognized even in the case without steroid use. Finally, eighty percent of the OLP cases showed significant efficacy, in addition, there was no significant adverse events due to the side effects. Thus, CEP use is considered to have significant efficacy for the treatment of OLP without side effects.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] A retrospective multi-institutional study on the clinical categorization and diagnosis of oral lichen plants2017

    • Author(s)
      Ito D, Sugawara Y, Jinbu Y, Nakamura S, Fujibayashi T, Maeda H, Hasegawa H, Saku T, Tanaka A, Komiyama K
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: in press Issue: 5 Pages: 452-457

    • DOI

      10.1016/j.ajoms.2017.03.010

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 口腔扁平苔癬(びらん型)に対する口腔衛生管理の実際.2017

    • Author(s)
      村野好、神部芳則、井上千恵子、森良之、菅原由美子、笹野高嗣.
    • Journal Title

      日本口腔内科学会雑誌

      Volume: 23 Pages: 40-45

    • NAID

      130006295380

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic performance of MR imaging of three major salivary glands for Sjögren's syndrome.2017

    • Author(s)
      I Kojima I, M Sakamoto , M Iikubo , H Kumamoto, A Muroi, Y Sugawara, S Satoh-Kuriwada, T Sasano
    • Journal Title

      Oral diseases  2017 Jan;23(1):84-90

      Volume: 23 Issue: 1 Pages: 84-90

    • DOI

      10.1111/odi.12577

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 口腔扁平苔癬に対するCepharanthineの臨床効果に関する後方視的多施設共同研究2016

    • Author(s)
      菅原由美子、神部芳則、笹野高嗣、草間幹夫、森 良之、北川善政、高橋 哲)、杉山芳樹、福田雅幸、川又 均、柴田敏之 、 植野高章 、 岸本裕充、飯田征二、中村典史、杉浦 剛
    • Journal Title

      日本口腔内科学会雑誌

      Volume: 22 Pages: 59-67

    • NAID

      130006908912

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 口腔扁平苔癬ワーキンググループ:口腔扁平苔癬全国調査に基づいた病態解析および診断基準・治療指針の提案.2015

    • Author(s)
      小宮山一雄、菅原由美子、他
    • Journal Title

      日口内誌

      Volume: 21

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 抗BP180抗体検査が陰性であった粘膜類天疱瘡の2症例2017

    • Author(s)
      菅原由美子、熊本裕行、笹野高嗣.
    • Organizer
      第55回日本口腔科学会北日本地方部会・第43回日本口腔外科学会北日本支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シンポジウム1 「歯科薬物療法の現状と課題 ―口腔の痛みに対する薬物治療―」 口腔粘膜疾患による疼痛症状への対処法.2017

    • Author(s)
      菅原由美子
    • Organizer
      第37回日本歯科薬物療法学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 合同シンポジウム1 『歯科に適応のない薬剤をどうするか』 口腔粘膜疾患の治療薬における現状と展望.2017

    • Author(s)
      菅原由美子
    • Organizer
      第27回日本口腔内科学会 第30回日本口腔診断学会 合同学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔扁平苔癬(びらん型)に対する口腔ケアの実際2016

    • Author(s)
      村野好、神部芳則、井上千恵子、森良之、菅原由美子、笹野高嗣
    • Organizer
      第26回日本口腔内科学会 第29回日本口腔診断学会合同学術大会
    • Place of Presentation
      岡山、日本
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔粘膜疾患に対する細胞診2016

    • Author(s)
      室井梓、菅原由美子、及川麻理子、熊本裕行、佐々木優、笹野公伸、佐々木啓一
    • Organizer
      第105回 日本病理学会
    • Place of Presentation
      仙台、日本
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔扁平苔癬における組織診断と細胞診断の比較検討2016

    • Author(s)
      菅原由美子、及川麻理子、今野かおり、三浦弘守、渡辺みか、熊本裕行、笹野高嗣
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡、日本
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Two-type classification of OLP from a nationwide survey in Japan2016

    • Author(s)
      Komiyama K, Itou D, Jinbu Y, Sugawara Y, et al
    • Organizer
      2016 AAOM
    • Place of Presentation
      Atlanta USA
    • Year and Date
      2016-04-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Two-type classification of OLP from a nationwide survey in Japan2016

    • Author(s)
      Kazuo Komiyama, Daisuke Ito, Yoshinori Jinbu, Yumiko Sugawara, Seiji Nakamura, Takashi Fujibayashi,Takashi Saku, Akio Tanaka, Hiromasa Hasegawa, Hatsuhiko Maeda
    • Organizer
      2016 merican Academy of Oral Medicine
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      2016-04-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] シェーグレン症候群に関連した肥厚性硬膜炎の1症例2015

    • Author(s)
      菅原由美子、古内壽、笹野高嗣
    • Organizer
      日本歯科放射線学会 第20回 臨床画像大会
    • Place of Presentation
      福岡
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔扁平苔癬治療におけるセファランチン投与例に対する臨床効果および有害事象の多施設・後方視的共同研究2015

    • Author(s)
      菅原由美子、神部芳則、他
    • Organizer
      第25回 日本口腔内科学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔扁平苔癬全国調査に基づいた病態解析および診断基準・治療方針の提案2015

    • Author(s)
      小宮山一雄、伊東大典、神部芳則、菅原由美子、他
    • Organizer
      第25回 日本口腔内科学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 扁平苔癬の問題点2015

    • Author(s)
      田中昭男、伊東大典、神部芳則、菅原由美子、他
    • Organizer
      第69回 日本口腔科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 口腔扁平苔癬を合併したGood症候群の1例2015

    • Author(s)
      菅原由美子、熊本裕行、笹野高嗣
    • Organizer
      第69回日本口腔科学会
    • Place of Presentation
      大阪市
    • Year and Date
      2015-05-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 口腔扁平苔癬を合併したGood症候群の1例2015

    • Author(s)
      菅原由美子、熊本裕行、笹野高嗣
    • Organizer
      第69回 日本口腔科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
  • [Presentation] OLP診療のガイドラインの構築に向けて2014

    • Author(s)
      伊東大典、神部芳則、菅原由美子、中村誠司、藤林孝司、小宮山一雄、長谷川博雅、朔敬、前田初彦、田中昭男
    • Organizer
      第24回日本口腔内科学会・第27回日本口腔診断学会合同学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 口腔扁平苔癬に関する二学会共同調査研究報告2014

    • Author(s)
      小宮山一雄、長谷川博雅、朔敬、前田初彦、田中昭男、伊東大典、神部芳則、菅原由美子、中村誠司、藤林孝司
    • Organizer
      第25回日本臨床口腔病理学会
    • Place of Presentation
      新潟市
    • Year and Date
      2014-08-29
    • Related Report
      2014 Research-status Report
  • [Book] 臨床家のための口腔疾患診断トレーニングブック2018

    • Author(s)
      神部芳則、笹野高嗣、菅原由美子、飯久保正弘、他9名
    • Total Pages
      120
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2017 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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