Therapeutic innovation in oral mucosal leasions with erosion and ulcer by analyzing antigen presenting ability and autophagy
| Project/Area Number |
26462832
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
笹野 高嗣 東北大学, 歯学研究科, 教授 (10125560)
菅原 俊二 東北大学, 歯学研究科, 教授 (10241639)
西岡 貴志 東北大学, 歯学研究科, 助教 (50641875)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔粘膜 / びらん・潰瘍病変 / 口腔扁平苔癬 / 抗原提示能 / オートファジー / 治療法 / 口腔粘膜疾患 / 剥離細胞診 / 組織細胞診 / 組織診断 / 細胞診断 |
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| Outline of Final Research Achievements |
Retrospective study was performed at 12 facilities on efficacy and safety of Cepharanthin (CEP) long-term use for the patient with oral lichen planus (OLP). The degree of the severity classified to, before and after 4weeks and 6 months and at the end point of the CEP use was assessed. The mean dosage period of the CEP use was 415 days, and the daily average dosage was 11.6mg. The high improvement rate was accepted in almost all clinical types and the location of the lesions by CEP use. Long-term use showed the higher efficacy for improving OLP. On the other hand, the dosage of CEP showed no significant difference for the improvement of OLP. High improvement rate was recognized even in the case without steroid use. Finally, eighty percent of the OLP cases showed significant efficacy, in addition, there was no significant adverse events due to the side effects. Thus, CEP use is considered to have significant efficacy for the treatment of OLP without side effects.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] A retrospective multi-institutional study on the clinical categorization and diagnosis of oral lichen plants2017
Author(s)
Ito D, Sugawara Y, Jinbu Y, Nakamura S, Fujibayashi T, Maeda H, Hasegawa H, Saku T, Tanaka A, Komiyama K
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: in press
Issue: 5
Pages: 452-457
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Two-type classification of OLP from a nationwide survey in Japan2016
Author(s)
Kazuo Komiyama, Daisuke Ito, Yoshinori Jinbu, Yumiko Sugawara, Seiji Nakamura, Takashi Fujibayashi,Takashi Saku, Akio Tanaka, Hiromasa Hasegawa, Hatsuhiko Maeda
Organizer
2016 merican Academy of Oral Medicine
Place of Presentation
Atlanta,USA
Year and Date
2016-04-06
Related Report
Int'l Joint Research
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[Presentation] 扁平苔癬の問題点2015
Author(s)
田中昭男、伊東大典、神部芳則、菅原由美子、他
Organizer
第69回 日本口腔科学会学術集会
Place of Presentation
大阪
Year and Date
2015-05-15
Related Report
Invited
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