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Roles of interleukin-33 in gingival Inflammation

Research Project

Project/Area Number 26462834
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Ohno Tatsukuni  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (80435635)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIL-33 / 歯周炎 / マウスモデル / 歯周病 / 歯肉炎モデル / 歯周炎モデル / LPS / P. gingivalis / 歯肉炎
Outline of Final Research Achievements

Interleukin-33 (IL-33), which is a new member of the IL-1 family of cytokines, has been involved in Th2-mediated immune responses including host defense against nematode and allergic diseases. Unlike regular cytokines, IL-33 is released from necrotic damaged cells during tissue injury and acts as an alarmin. Thus, IL-33 may contribute to chronic inflammatory tissue diseases. In this study, we investigate the roles of IL-33 in the gingival inflammation. Wild-type and IL-33 knockout (KO) mice received Porphyromonas gingivalis (P.g)-injection into the molar gingiva and gingival inflammatory responses were evaluated. LPS-injection into gingiva enhanced IL-1b, TNF-a, and IL-33 mRNA expression in wild type mice, but not in IL-33 KO mice. Our results suggest dual roles of IL-33; protective role in early gingival inflammatory responses.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Immune checkpoint molecule, VISTA regulates T cell-mediated skin inflammatory responses2017

    • Author(s)
      Ohno T, Kondo Y, Zhang C, Kang S, Azuma M
    • Journal Title

      J Invest Dermatol

      Volume: 印刷中 Issue: 6 Pages: 1384-1386

    • DOI

      10.1016/j.jid.2016.10.049

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.2015

    • Author(s)
      Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      Immunity

      Volume: 43 Issue: 1 Pages: 175-86

    • DOI

      10.1016/j.immuni.2015.06.021

    • NAID

      40020962854

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Endogenous and exogenous IL-33 promotes antitumor immunity2015

    • Author(s)
      Nishii Naoto, BHINGARE Arundhati, OHNO Tatsukuni, KONDO Yuta, AZUMA Miyuki
    • Organizer
      第44回日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Involvement of endogenous or exogenous IL-33 in antitumor immunity2015

    • Author(s)
      西井 直人,Arundhati Bhingare,近藤 雄太,大野 建州,東みゆき
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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