| Project/Area Number |
26462837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tottori University |
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Principal Investigator |
RYOKE KAZUO 鳥取大学, 医学部, 特任教授 (20093635)
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| Co-Investigator(Kenkyū-buntansha) |
山本 哲也 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00200824)
上山 吉哉 山口大学, 医学(系)研究科(研究院), 教授 (00168668)
萩野 浩 鳥取大学, 医学部, 教授 (80208412)
小谷 勇 鳥取大学, 医学部, 准教授 (10294315)
本城 正 鳥取大学, 医学部附属病院, 講師 (10379844)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | HSC：ヒト間葉系幹細胞 / ＢＲＯＮＪ：ビスフォスフォネート関連顎骨壊死 / ヒト皮膚線維芽細胞 / 歯周靱帯線維芽細胞 / 細胞増殖能 / ＢＰ：ビスフォスフォネート / 骨芽細胞 / 骨免疫 / BRONJ / 皮膚線維芽細胞（NHDF) / 口腔由来の歯周靱帯線維芽細胞（HPｄLF） / 線維芽細胞の遊走能 / 線維芽細胞の増殖能 / 線維芽細胞成長因子（ｂFGF） / MC3T3 / rPTH / OC / OC-Luc / MMCT / IMMUNOLOGY / MAC / MSC / ＢＲＯＮＪ / ＯＣ / ＭＳＣ / ＭＡＣ / ＭＭＣＴ / ＯＣ－Ｌｕｃ |
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| Outline of Final Research Achievements |
1.We established HSC(Human Mesenchymal Stem Cell) enabling to monitor of bone differentiation.As for the remedy against BRONJ, the medication of PTH was examined using this HSC derived from the human bone marrow.The optimum administration of PTH was a dosage of 100ng/ml with 4-day intervals.An addition of BP to HSC demonstrated no any bone formation,which implied that BP could supress the osteoblastic formation. 2.BP inhibited both NHDF and HPdLF proliferation in dose dependency,especially the tendency was remarkable in the latter.Inhibiting of cell migration was marked in HPdLF.An expression of bFGF was detected in both HPdLF and NHDF groups after BP processing,but there was no signiticant difference between them.
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