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Involvement of NLRP3 inflammasome in oral lichen planus

Research Project

Project/Area Number 26462842
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKochi University

Principal Investigator

KITAMURA Naoya  高知大学, 教育研究部医療学系臨床医学部門, 講師 (70351921)

Co-Investigator(Kenkyū-buntansha) 山本 哲也  高知大学, 教育研究部医療学系臨床医学部門, 教授 (00200824)
笹部 衣里  高知大学, 教育研究部医療学系臨床医学部門, 講師 (40363288)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsインフラマソーム / 口腔扁平苔癬
Outline of Final Research Achievements

Although the pathogenesis of oral lichen planus (OLP) has not been elucidated, the possibility of an immune response based on localized excessive cytokine toward mucosal epithelial cells has been suggested. In this study, we investigated whether the activation of NLRP3 inflammasome is involved in the pathogenesis of OLP. As a result, it was revealed that the activation of NLRP3 inflammasome by metal nanoparticles in the oral mucosal epithelial cells and macrophages was involved with the pathogenesis of OLP.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results)

  • [Presentation] 口腔粘膜細胞における歯科用金属のインフラマソームへの影響2016

    • Author(s)
      笹部衣里・仙頭慎哉・北村直也・山本哲也
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔粘膜上皮細胞のインフラマソームに及ぼす金属ナノ粒子の影響2016

    • Author(s)
      笹部衣里、仙頭慎哉、北村直也、山本哲也
    • Organizer
      第53回日本口腔組織培養学会学術大会
    • Place of Presentation
      石川県立美術館(石川県金沢市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平苔癬の病態形成におけるインフラマソームの関わり2015

    • Author(s)
      笹部衣里、浜田真友子、CHONG LI、冨田理生、仙頭慎哉、山本哲也
    • Organizer
      第25回日本口腔内科学会学術集会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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