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Drafting of a revised ACR criteria for Sjogren's syndrome.

Research Project

Project/Area Number 26462844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNagasaki University

Principal Investigator

TAKAGI Yukinori  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30295084)

Co-Investigator(Kenkyū-buntansha) 中村 英樹  長崎大学, 病院(医学系), 講師 (10437832)
佐々木 美穂  長崎大学, 病院(歯学系), 助教 (10437874)
中村 卓  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30172406)
角 美佐  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (90284702)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsシェーグレン症候群 / 超音波 / 診断基準 / ACR診断基準 / systematic review
Outline of Final Research Achievements

Incorporating the US criteria as an alternative to one of the three ACR classification items achieved 89-91% sensitivity, 87-96% specificity and 89% or 92% accuracy, which was comparable to that of the original ACR classification. Furthermore, kappa analysis indicated that the results of the original ACR and US-replaced ACR classifications matched completely (κ = 0.960-0.974).Therefore,US can be used as an alternative to any of the three ACR classification items.
Also.multiple regression analysis indicated that the baseline US score before treatment was the most important factor [standardized regression coefficient (β) = -0.523, t-statistic (t) = -7.967, P < 0.001] in predicting negative outcomes in SS patients. Salivary gland US grading may help to predict outcomes of treatment for impaired salivary function in patients with SS.
These results suggest that US is a promising technique,which can be used as a practical item in the classification criteria of SS.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Salivary gland US as a primary imaging tool for predicting efficacy of xerostomia treatment in patients with Sjogren's syndrome.2016

    • Author(s)
      Takagi Y,Sumi M.Nakamura H,Horai Y,Kawakami A,Nakamura T
    • Journal Title

      Rheumatology

      Volume: 55 Issue: 2 Pages: 237-45

    • DOI

      10.1093/rheumatology/kev278

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ultrasonography as an additional item in the American College of Rheumatology classification of Sjogren’s syndrome.2014

    • Author(s)
      Takagi Y, Sumi M, Nakamura H, Horai Y, Kawakami A, Nakamura T
    • Journal Title

      Rheumatology

      Volume: 53(11) Issue: 11 Pages: 1977-83

    • DOI

      10.1093/rheumatology/keu238

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 当院における口腔乾燥症外来の取り組み~ドライマウスの診断と治療~2016

    • Author(s)
      高木 幸則
    • Organizer
      長崎シェーグレン症候群研究会
    • Place of Presentation
      ベストウェスタンプレミアホテル長崎(長崎県・長崎市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 超音波画像診断によるシェーグレン症候群の治療効果予測2015

    • Author(s)
      高木幸則
    • Organizer
      第24回シェーグレン症候群学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都・ 新宿区)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] シェーグレン症候群およびIgG4関連疾患における唾液腺超音波 画像診断の有用性2014

    • Author(s)
      中村 卓
    • Organizer
      第23回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      長崎ブリックホール(長崎市)
    • Year and Date
      2014-09-12 – 2014-09-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] リウマチ科 ~シェーグレン症候群における唾液腺超音波検査の有用性~2016

    • Author(s)
      高木 幸則
    • Publisher
      科学評論社
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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