| Project/Area Number |
26462845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SASAKI Miho 長崎大学, 病院(歯学系), 助教 (10437874)
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| Co-Investigator(Kenkyū-buntansha) |
中村 卓 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30172406)
角 美佐 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (90284702)
佛坂 由可 長崎大学, 病院(歯学系), 講師 (10244089)
片山 郁夫 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (80295089)
榮田 智 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (80325662)
高木 幸則 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30295084)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | SUV / ＦＤＧ－ＰＥＴ / 転移リンパ節 / ＭＲＩ / リンパ節転移 / MRI / FDG-PET / ＰＥＴ／ＣＴ / ＦＤＧ |
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| Outline of Final Research Achievements |
We evaluated the FDG uptake of the metastatic lymph adenopathy of head and neck malignant tumors using in vivo and in vitro methods. In vivo assessment, it is appeared that cPLA2 knock-out mice had less tendency to lymph node metastasis compared with wild type. It is supposed that angiogenetic feature is different between these two groups, that causes the difference in the glucose metabolism. In vitro assessment, we evaluated the SUVs and Diffusion -weighted imaging parameters of head and neck malignant tumors with or without lymph nodes metastasis. As the increase of SUVmax of primary tumors, the SUVmax of metastatic lymph nodes also increases, but not significant. SUVmax of the metastatic lymph node correlates Diffusion-weighted MR parameters, such as ADC. It is appeared that necrotic area within the metastatic lymph nodes influences the SUV uptake and ADC of the metastatic lymph nodes.
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