| Project/Area Number |
26462846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Oita University |
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Principal Investigator |
kawano Kenji 大分大学, 医学部, 教授 (50214664)
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| Co-Investigator(Kenkyū-buntansha) |
吉岡 俊一 大分大学, 医学部, 客員研究員 (20599659)
高橋 喜浩 大分大学, 医学部, 客員研究員 (60347028)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 口腔扁平上皮癌 / 浸潤・転移抑制療法 / integrin / ILK / laminin 5 / HIF 1α / Her3/ErbB3 / 浸潤 / 転移 / 細胞接着 / カドヘリン / インテグリン / 細胞外マトリックス |
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| Outline of Final Research Achievements |
This research project aims at the establishment of anti-invasion/metastasis therapy against oral squamous cell carcinomas (OSCC). OSCC of the tongue and oral floor were examined for expression of integrin-linked kainase (ILK), laminin 5, hypoxia-induced factor 1α (HIF 1α) and Her3/ErbB3. ILK was overexpressed in 67% of OSCC, and it was localized on cell membrane or in cytoplasm of cancer cells. Since ILK did not co-localized with laminin 5 in most of tumors, it was likely that ILK did not mediate the out-in signal via α3β1 integrin. When ILK overexression was compared with T classification, invasion pattern of cancer cells and treatment outcome, no clear correlations were observed between ILK and all of these factors. In conclusion, no molecular basis of the possibility of a novel molecular therapy targeting ILK has not been obtained yet.
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